ABSTRACT
Simulaneous administration of propranolol and verapamil is toxic to the experimental animals. The total and differential serum calcium level and serum protein level were estimated in 4 groups of rabbits. One group received propranolol, the second received verapamil, the third received both drugs and the fourth received both drugs plus calcium. Significant increase in the level of serum ionized calcium was observed in the 4 groups. The result indicates that these drugs induce their toxic interacation through the blockade of calcium channels
Subject(s)
Propranolol , Verapamil , Animals, Laboratory , Drug InteractionsABSTRACT
Ephedrine was evaluated in the injectable form of two different pharmaceutical brands of local drug companies. Biological and chemical methods were applied for this purpose. The biological method explored the effect of ephedrine on the rate The chemical procedure depended on the general titration method. The results were statistically evaluated in comparison to standard ephedrine