ABSTRACT
OBJECTIVE@#To assess the efficacy of Hibiscus sabdariffa (H. sabdariffa) and Telfairia occidentalis (T. occidentalis) extracts in the attenuation of CCl4-mediated oxidative stress.@*METHODS@#Seventy-two healthy matured male albino rats weighing between (120±20) g were divided into 6 groups (A-F) in a 2×6 factorial experiment using completely randomized design. Rats in Group A received only water, B received 1 mL/kg CCl4, C received 300 mg/kg, D received 600 mg/kg, E received CCl4+300 mg/kg while F received CCl4+600 mg/kg for each of the extract, respectively. Semen from epididymes was obtained for sperm analysis while blood was obtained through cardiac puncture for biochemical analysis, after the treatment regimen.@*RESULTS@#Our results showed that CCl4 induction elevated aspartate aminotransferase, alanine transaminase, alkaline phosphatase, total protein, globulin levels significantly (P<0.05) while albumin was reduced. For sperm profile after CCl4 induction, sperm count, viability and motility were significant (P<0.05) reduced while sperm head abnormality increased. However, administering H. sabdariffa and T. occidentalis extracts at the doses of 300 and 600 mg/kg caused the reversal of these effects significantly.@*CONCLUSIONS@#Implicitly, the implication of our results is that H. sabdariffa and T. occidentalis extracts might be ted and optimized for the management of oxidative stress-related organ injuries, including infertility, though further researches are needed.
ABSTRACT
Objective: To assess the efficacy of Hibiscus sabdariffa (H. sabdariffa) and Telfairia occidentalis (T. occidentalis) extracts in the attenuation of CCl