ABSTRACT
This study examined the type of medicinal plants used in the management of malaria in the Yoruba folklore in south western Nigeria. 87 Traditional medicine practitioners (TMP's) were interviewed. Plants available in the regions were considered in the survey and recorded with their local names; parts used; preparation and the modes of use. A total of 21 plant species used by TMP`s in the management of malaria infections were identified. These species belong to 18 plant families
Subject(s)
Disease Management , Malaria , Medicine, Traditional , Nigeria , Plants, MedicinalABSTRACT
This study examined the type of medicinal plants used in the management of malaria in the Yoruba folklore in south western Nigeria. 87 Traditional medicine practitioners (TMP's) were interviewed. Plants available in the regions were considered in the survey and recorded with their local names; parts used; preparation and the modes of use. A total of 21 plant species used by TMP`s in the management of malaria infections were identified. These species belong to 18 plant families
Subject(s)
Malaria/therapy , Medicine, African Traditional , Nigeria , Plants, MedicinalABSTRACT
The aqueous leaf; stem - bark; seed and fruit pericarp extracts of Pentaclethra macrophylla were examined for their cytotoxicity; while only the leaves and seeds were tested for analgesic and anti-inflammatory activities using in-vivo and in-vitro experimental models. Cytotoxicity haemagglutination assay revealed the following order of toxicity among the plant parts: fruit pericarp stem - bark seed leaf with 71.4; 25.6; 5.3; and 0.5 haemagglutination titre values respectively. The extracts at 30 and 60 mg/kg exhibited analgesic activity and anti-inflammatory property using the flick and hot plate tests; acetic acid induced writhing test; and leucocyte counts; pulmonary oedema and oedema paw of mice in a dose-dependent manner. These findings therefore explain and justify ethnomedical uses of Pentaclethra macrophylla in the treatment of itching (inflammatory response) and pain in animals and in man
Subject(s)
Hemagglutination , Medicine , PlantsABSTRACT
Dorstenia barteri and D. convexa extracts and some isolated components of the former were investigated for effectiveness against Trichomonas gallinarum and compared with quercetin and quercitrin. The antioxidant activity of the extracts/compounds was also determined. The minimum lethal concentrations (MLCs) for the extract of D. barteri leaves and twigs at 24 h were found to be 15.625 and 15.625 æg/ml, respectively. However, the MLCs of the leaf and twig extract of D. convexa were 125 and 437.5 æg/ml, respectively. The prenylated and geranylated chalcones were as active as the prenylated flavones, 6-prenylapigenin and the diprenylated derivative 6,8-diprenyleridictyol. The order of the antitrichomonal activity of the compounds at 24 h was: quercetin (0.121 æg/ml) > quercitrin (0.244 æg/ml) > or = bartericin B (0.244 æg/ml) > bartericin A (0.73 æg/ml) > stigmasterol (0.98 æg/ml) > 6,8-diprenyleridictyol = isobavachalcone = dorsmanin F (31.25 æg/ml). D. barteri extracts, quercitrin, and bartericin A, and the prenylated flavonoids had potent antioxidant properties. The twig extract of D. barteri was more potent than the leaf extract. Moderate (EC50 >50 æg/ml) and high (EC50 <50 æg/ml) antioxidant activities were detected in the leaf and twig extracts of D. barteri and the prenylated flavonoids. Prenylated flavonoids and the isolated compounds with antioxidant properties described here may account for the anti-inflammatory action of these extracts. The antitrichomonal and antioxidant activities shown by the extracts and compounds in this study are consistent with the ethnomedicinal and local use of the Dorstenia species studied.