ABSTRACT
Background: Coronary artery disease [CAD] is one of the greatest causes of morbidity and mortality worldwide. It is the principal threat to health in countries in Africa and the Middle East and one of the leading causes of disease burden in developing countries. Scavenger receptor class B type1 [SCARB1] is a multiligand cell surface receptor. This membrane protein facilitates the uptake of cholesterol esters from highdensity lipoprotein cholesterol [HDL-C] and drives cholesterol from tissues to the liver in the various stages of reverse cholesterol transport pathway
Aim: The aim of this work is to study the association of rs5888 polymorphism of SCARB1 gene and premature coronary artery disease
Patients and Methods: PCAD group included 50 patients newly diagnosed angiographically with premature coronary artery disease, and non-PCAD group that included 50 age and sex matched non-CAD individuals who showed no luminal stenosis in coronary angiographic results
Results: The frequency of the wild type [CC] was higher in the control group [56%] than patients' group [18%] and it can be considered as a negative risk factor for PCAD [OR: 0.172, 95% CI [0.0693-0.429], p < 0.01]. The homozygous and heterozygous mutations [TT and CT] were statistically more frequently distributed in PCAD patients compared to control subjects [34 % and 48 % respectively], however only the CT genotype was considered as positive risk factor for PCAD [OR: 4.205, 95% CI[1.692-10.448], p= 0.01]
Conclusion: Allele frequencies of studied SCARB 1 SNP revealed a higher frequency of distribution of T alleles in patients' group when compared with control group, on the other hand it shows the higher frequency of distribution of C alleles in control group when compared to patients' group
ABSTRACT
Background: red cell distribution width is a marker associated with increased mortality and morbidity in cardiac patients, however it's relation with coronary artery calcium score [CACS] is not well studied yet
Aim of the work: this study aimed to assess the relation between red cell distribution width [RDW] and coronary artery calcium score [CACS] in the diabetic patients undergoing coronary CT angiography
Patients and methods: this study was conducted on 60 patients presented for assessment of coronary artery disease [CAD] by coronary CT angiography and they were categorized into 2 groups, group [A] diabetics[30 patients],group[B]non-diabetics [30 patients], All patients included in this study were subjected to: History Taking, complete physical examination, multi-slice CT coronary angiography [MSCT] including calcium score[CACS], laboratory investigations including complete blood count [CBC] including RDW[SDandCV], serum calcium level[total and ionized], erythrocyte sedimentation rate [ESR], lipid profile
Results: higher RDW[SD] was associated with the presence of greater coronary complexity of CAD and higher calcium score. In our study total serum calcium and RDW [SD] were found to be independent predictors of high Ca score more than 100, while ionized calcium and systolic blood pressure[SBP] were independent predictors of high Calcium score more than 400. Cut off value of RDW to predict high calcium score [more than 100] was RDW[CV] more than 13.45 and RDW[SD] more than44.45, while Cut off value of RDW to predict high calcium score [more than 400] was RDW[SD] more than 45.1
Conclusions: a greater baseline RDW[SD] value was independently associated with the presence of a greater coronary complexity of CAD and higher calcium score