ABSTRACT
To study the efficacy of dydrogesterone in pregnant women with threatened miscarriage in the first trimester. Randomized control trial. Department of Obstetrics and Gynaecology, Military Hospital Rawalpindi from Jan 2008 to Dec 2008. One hundred and fifty two pregnant women presenting to the Gynae and Obs department [MH Rwp] before 12[th] gestational week were selected on the basis of slight pain or vaginal bleeding, no cervical dilatation and a viable pregnancy on ultrasound. They were divided randomly into two groups each containing 76 patients with the help of simple random number table, after obtaining their consent and explaining all the risks and benefits to them. Bias was controlled by double blinding. Patients in group A received oral dydrogesterone [10mg twice daily] and patients in group B received placebo. Treatment was continued till the 12[th] gestational week and patients were followed up 4 weekly after the completion of treatment till the 20[th] gestational week. Improvement was judged by continuation of pregnancy and remittance of symptoms. Patients in group A had a greater improvement in the symptoms of pain and vaginal bleeding but the difference between the two groups was not statistically significant. However the number of patients who had a normal growth and whose pregnancies continued was significantly higher in group A. It was concluded that the continuing pregnancy success rate was significantly higher in women treated with dydrogesterone compared with women who received placebo treatment
ABSTRACT
To determine the frequency and the types of anemia in a specific sample of patients reporting to Combined Military Hospital, Rawalpindi. Design and A descriptive study with retrospective data was conducted in outdoor patients department of Combined Military Hospital, Rawalpindi by screening/testing haemoglobin and haematocrit in the third trimester of pregnancy. Five hundred patients that reported to outdoor patient department of Combined Military Hospital, Rawalpindi from July 2002 to January 2003, were selected for study according to the inclusion and exclusion criteria by convenience sampling. Study was carried out on automated electronic cell counters and chemical analyzers. Any abnormal results in routine investigations were followed up. Inclusion criteria was educated women with at least a high school degree in their third trimester with age ranging between 20 to 30 years, gravidity between 1 to 3 and birth spacing of at least 2 years. The significant out come of the study was that iron deficiency anemia exists substantially in this socioeconomic group [educated middle class]. Out of the total 500 cases, 241 [48.2%] were found to be anemic, according to the severity was 39.8% mild, 7.6% moderate and 0.8% severe anemia. The mean + SD haemoglobin was 10.3 +/- 0.3 g/dL for mild, 8.9 +/- 0.41 g/dL for moderate and 6.8 +/- 0.22 g/dL for severe anemia. Seventeen patients out of the original sample were lost to follow up. The major categories of anemia to effect the study sample were iron deficiency anemia and beta thalassaemia trait. The percentages obtained were 41.6% and 4.8% respectively. Iron deficiency is quite frequent during third trimester of pregnancy is our study population. A comprehensive research in our country is needed on how to improve existing iron supplementation programs and the overall health care and nutritional status of women before they enter their reproductive years