Carcinoma of pancreas: an ultrastructural study

20 cases of adenocarcinoma of pancreas were included in this study. They were 13 men and 7 women with age range 36-70 years. These cases were operated in department of General Surgery, Zagazig University.Histopathologic diagnosis revealed 6 cases were well differentiated and 12 cases were moderate while 2 cases were poorly differentiated. E/M study of all cases showed that the most common affected organelle was the mitochondria and the nuclear change were essential as a landmark of malignancy. Light microscopic differentiation between pancreatic well differentiated adenocarcinoma and other pancreatic lesions as chronic pancreatitis was difficult in some cases. So E/M examination is an important modality in diagnosis of such cases