ABSTRACT
Inhibition of angiogenesis has been proposed as a novel therapeutic approach to the treatment of chronic inflammatory diseases. Chlorpyrifos methyl is a widely used organophosphate insecticide, used extensively in agriculture, public health and as a household insecticide. The aim of the present work is to study the influence of chlorpyrifos methyl on the experimentally induced models of angiogenesis and inflammation. Female Sprague Dawely rats were divided into two main groups. Control animals were kept feeding normal control diet and the treated animals were fed diet containing chlorpyrifos methyl [10 times the acceptable daily intake] for 30 days. After 24 hours, animals of each group were subdivided into 3 subgroups in which the following three animal models were induced: 1- Rat paw edema model. 2- Cotton pellet granulation tissue model. 3- Air pouch carrageenan induced model. Results showed that chiorpyrifos methyl in low doses induced significant increase in the granulation tissue weight and significant increase in pouch fluid volume after 3 days. It has also induced significant increase in the number of leucocytes in the pouch fluid and in the formation of new blood vessels [angiogenesis] in the whole granulation tissue after 3 and 6 days