Expression of Salivary Resistin in Oral Premalignant Individuals

Introduction:Resistin, (Retn) a pro -inflammatory cytokine, accumulates at the site of inflammation.It is found to be elevated in chronic inflammation. The aim of this present study is to evaluate the levels of salivary resistin in healthy individuals and in patients with Oral pre-malignant lesion.Materials and Methods: This case control study comprises of total 90 patients which includes 45 healthy controls and 45 cases diagnosed with oral pre-malignant lesions. Salivary levels of resistin and clinical parameters were evaluated in all of them. Socio -demographic data (age, gender and residence) was collected from all participants through a questionnaire. In addition, we also recorded the total duration of tobacco usage (in years), daily frequency, and intra-oral examination and oral hygiene practices. This was followed by evaluation of clinical parameters of oral premalignant lesions and investigation of salivary levels of resistin through ELISA Results: Thesaliva of all the patients showed presence of resistin. On analyzing the samples present study shows no significant difference and variation in the salivary levels of resistin in healthy and OPML patients.Conclusion: With the results of this study, it can be concluded that there is no significant difference in the salivary levels of resistin in healthy individuals and individuals diagnosed with oral pre-malignant lesion

Topical application of tocopherol with corticosteroid in reducing the early signs and symptoms of oral submucous fibrosis patients

Objective: The aim of this study was to compare the topical application of steroid alone or with combination use of steroid and tocopherol in reducing oral mucositis in Oral Submucous Fibrosis [OSMF], patients

Methods: In Pakistani population a rapidly advancing premalignant condition, Oral submucous fibrosis [OSMF] is present which has deteriorated the quality of life. The study was conducted in Department of Oral Medicine and Diagnosis, College of Dentistry, Ziauddin University Karachi, from December 2013 till July 2015. Randomly selected 76 patients with diagnosed OSMF, with history of chewing areca/betal nut or other similar products, with burning sensation on having spicy ingredient, trismus >20mm with or without palpable fibrous bands on the buccal mucosa intraorally with rigidity and blanching were included in the study. Total 38 out of 76 patients were given a combination of topical tocopherol application100mg and betamethasone [betonil 0.1%] twice daily and remaining 38 were on topical rinse of betamethasone [betonil 0.1%] alone. OSMF patients were clinically examined to assess the mouth opening and other clinical symptoms during three months and were followed up for next two months

Results: In the amelioration of early signs and symptoms of OSMF topical tocopherol combination with steroid application was found to be significantly efficacious. Objective signs of OSMF were reduced with improved mouth opening in 69.56% [p<0.05] of the cases

Conclusion: This study has shown that tocopherol, appears to be an effective drug in treating the early signs of OSMF

Oral submucous fibrosis: successful management of fifty cases with interpositioning buccal Fat Pad Flap

Objective: The aim of this study was to evaluate the clinical and anatomical application of buccal fat pad as an interpositional material in the surgical treatment of oral submucous fibrosis [OSMF] for improvement of mouth opening and its movements

Methods: OSMF has become a chronic, distressing condition of uncertain aetiology in Pakistan which rapidly involves the oral structures along with other parts of upper gastrointestinal tract

The study was conducted in Department of Oral and Maxillofacial Surgery, Ziauddin College of Dentistry, Ziauddin University, Karachi, from December 2013 till July 2015. We evaluated 50 diagnosed OSMF patients, with history of chewing areca/betal nut or other similar products, with burning sensation on having spicy ingredient, trismus 4-25mm with palpable fibrous bands on the buccal mucosa intraorally with rigidity and blanching were included in the study. Good clinical improvement with minimal morbidity by the use of buccal fat pad was noticed in patients with severe limited mouth opening along with regular and vigorous physiotherapy

Results: In 50 patients, the range of preoperative mouth opening was 4-24mm [14 +/- 4.90], the intra operative mouth opening was 25-38mm [33.25 +/- 4.17]. The patients were discharged after 72 hours at this time mouth opening was 25-36mm [0.63 +/- 3.82]

Comparison of pre-operative with intra and post-operative mouth opening was statistically significant

Conclusion: This study has shown that use of interpositioning buccal fat pad flap improves the mouth opening and movement in OSMF patients

unusual presentation of [peripheral giant cell granuloma]

Peripheral giant cell granuloma is an uncommon lesion though not rare in the oral cavity. A case is reported where peripheral giant cell granuloma was associated with partially impacted mandibular canine. The presentation was interesting because the lesion was initially diagnosed as tuberculosis and the patient was treated with anti tuberculous drugs for nine months without any regression of the oral lesion. The case report emphasizes the importance of history, examination and investigation in diagnosis