ABSTRACT
Aim of the Study: to assess the merits and demerits of posterior pericardial drainage in patients undergoing heart surgery
Materials and Methods: a systematic review and meta-analysis of observational studies and randomized controlled trials was conducted. We searched for relevant trials in the Cochrane Library, MEDLINE [from 1980], Embase from 1970 the Transfusion Evidence Library from 1980, and ongoing trial databases; all searches current to 30 September 2017
Results: the search yielded sixteen randomized controlled trials which included 2755 patients. Results revealed that Posterior pericardial drainage was associated with a significant 90% reduction of the odds of cardiac tamponade versus the control group: [OR 95% confidence interval] 0.13; P < 0.001. The ORs of death or cardiac arrest were significantly decreased by approximately 50% in the posterior pericardial drainage group compared to controls: OR [95% CI]: 0.47, P = .028; I2 = 0%
Conclusion: posterior pericardial drainage has been reported in the literature to significantly reduce the prevalence of early pericardial effusion as well as cardiac tamponade. A significant enhanced survival rate was recorded postcardiac surgery
ABSTRACT
Aim of the Study: to conduct a systematic review and meta-analysis of prospective cohort studies of the association of vitamin D deficiency with onset of depression in non- depressed individuals
Methods: a systematic review of the electronically searched publications of the scientific literature. We searched the Cochrane Hepato Biliary Group Controlled Trials Register, Cochrane Central Register of Controlled Trials in The Cochrane Library, MEDLINE [1946 to 2017], EMBASE [1974 to 2017], and Science Citation Index Expanded [1900 to 2017]. Initially all randomized clinical trials which studied the correlation of Vitamin D with depression were included; articles were then selectively screened according to the eligibility criteria
Results: the search yielded 11 studies; A meta-analysis of all studies without flaws demonstrated a statistically significant improvement in depression with Vitamin D supplements [+0.72 CI +0.28, +1.31]. Nevertheless, studies with biological flaws were mainly inconclusive
Conclusion: our analyses are consistent with the hypothesis that Vitamin D supplementation [>/=800 I.U. daily] was supported in the management of depression