Darier's Disease Of Moderate Severity With Mucosaland Nail Involvement

Darier's disease, also known as keratosis follicularis, dyskeratosis follicularis or Darier-White disease, is a rare, inherited, acantholytic disorder caused by mutation in ATP2A2 gene, which manifests with hyperkeratotic lesions of variable severity. It typically occurs in young age and presents with itching and greasy appearance. The lesions are persistent and disease follows a chronic course with protean prognosis. Extracutaneous involvement may occur in mucosa, nail, eye and salivary gland.We report a case of Darier's disease of teenage onset, and moderate severity with palmoplantar, mucosal and nail involvement.

A Case Of Parthenium Dermatits In A Middle Aged Female

Parthenium dermatitis is an immuno-inflammatory disease caused by Partheniumhysterophorus and is the most common cause of plant dermatitis in India. Contact sensitivity to parthenium is everlasting, and hence the disease runs a chronic course with exacerbation during summers. Patch testing with acetone or aqueous plant extract is the simplest way of confirming parthenium contact allergy. We report a case of 40yr old female who presented with generalised erythematous and lichenified plaques and was managed effectively with topical corticosteroid and avoidance of allergens

A Case Of Chemical Leukoderma Effectively Treated With Punch Graft Surgery

Chemical leukoderma is a hypomelanotic disorder due to destruction of melanocytes or inhibition of melanogenesis secondary to application of harmful chemicals household or industrial. It can be easily diagnosed clinically by a positive history of frequent exposure to a depigmenting agent at the site corresponding with the pattern of the object applied. It has a psychosocial significance because of the dyspigmented presentation of the disease which often simulates other conditions associated with social stigma, like leprosy or vitiligo. Here, we report a case of thirty year old female with chemical leukoderma who presented to us with depigmented patches over forehead (bindi leukoderma) and dorsae of feet (footwear dermatitis) caused by application of sticker bindi and wearing of rubber footwear respectively. Complete repigmentation was observed after treatment with topical corticosteroids and melanocyte transfer surgery.