ABSTRACT
Background: Supply of safe blood starts with healthy voluntary non remunerated blood donors. Blood donor screening and testing for TTI has become stringent all over the world. A fundamental part of preventing TTI is to notify and counsel reactive donors which help in preventing secondary transmission of infectious disease.Methods: This observational descriptive study is done to determine the number of contacted TTI reactive donors and their response rate after notification of their abnormal tests. It includes all the sero-reactive donors from July 2015 to June 2016 in the department of IHBT, GGSMCH. Blood donors who were sero-reactive for any TTI were recalled and tested again with ELISA kit of different manufacturer or lot number and by rapid card tests. Donors’ sero reactive on repeat testing were informed, counseled and referred to ICTC (for HIV) or Physician (for hepatitis B and hepatitis C). Confidentiality was maintained at every level.Results: During the study period, numbers of blood donors were 12621, out of which 343 blood donors were found to be sero-reactive. 23 donors were HIV, 230 Hepatitis C, 90 were HBsAg reactive. We could contact 182 out of 343 sero reactive donors telephonically. 161 sero-reactive did not attend blood bank phone call or their contact number was changed. Amongst the 182 contacted donors, 72 donors responded for the notification call and attended counseling.Conclusions: Response rate among reactive donors is quite low and a big challenge. This shows poor health care knowledge and social stigma regarding TTI among donors.
ABSTRACT
Background: Platelet Transfusion are used for the treatment and prevention of bleeding in patients with decreased number and function of platelets. Platelet for transfusion can be provided by platelet concentrates, which are obtained either by PRP or buffy coat method from whole blood or by apheresis. Platelet Recovery in a patient is influenced by the transfused dose of platelets which in turn is dependent on the platelet yield. Aim of Study: In this study, our main objective is to identify the donor parameters that influence the platelet yield obtained by apheresis.Methods: This prospective study was undertaken in the Department of IHBT.140 healthy donors were selected for plateletpheresis according to guidelines laid down by Drugs and cosmetics Act over a period of one year. The plateletpheresis procedures were performed on Haemonetics MCS plus separator. Yield predicting donor variables included in the study were Age, Gender, Haemoglobin concentration, Haematocrit and Platelet count. The relationship between predonation donor variable and yield was studied using pearson correlation. Results: The Mean platelet yield was 3.19±0.48×1011per unit. Mean predonation platelet count of donor was 2.77± 0.46×105/μl. Mean age of the Donor was 30.31±8.14. Positive Correlation was observed between platelet yield and predonation platelet count of donor(r=0.318, P value 0.0001) which is significant. No such correlation was seen between platelet yield and Haemoglobin(r=0.131, P value 0.122), Haematocrit (r=0.058, P value 0.499), Age of Donor(r=0.034, P value 0.692). Conclusion: The possibility of obtaining higher platelet yield reduces the frequency of platelet transfusion and number of donor exposures with important consequent clinical and economic advantages.