ABSTRACT
Objective To evaluate silicon level in normal skin tissue
Methods The silicon levels in skin samples were measured using an atomic absorbance spectrophotometer in 37 healthy normal females who had never received silicone injection and compared with those who had developed granuloma after silicone injection
Results Low silicon level [44.07+/-75.86 microgram/g] was found in skin tissues of normal individuals as compared to those who developed post-silicone granuloma [1709.21+/-1851.72 microgram/g]
Conclusion Silicon may be found in normal skin tissue due to daily use of cosmetic products; however the level is significantly low
ABSTRACT
Background: Seropositive leprosy individuals have a tendency to experience a change into leprosy lepromatous type. Previous studies have demonstrated that the activity of indoleamine 2, 3-dioxygenase [IDO] in patients with lepromatous type leprosy is higher than those with tuberculoid type leprosy. However, no study has been available showing how IDO level can be correlated to seropositive subjects
Methods: Our observational cross-sectional study was conducted in Brebes, Central Java, Indonesia. Leprosy seropositivity was determined by measuring the level of anti-phenolic glycolipid-1 IgM and IDO level using ELISA
Results: Result of The IDO level in seropositive leprosy subjects was higher compared to those who were seronegative [p = 0.048]
Conclusion: In the early stage of leprosy infection, a high level of IDO level can already be found; therefore, it can affect immune response and ultimately affecting further course of the disease