ABSTRACT
Purpose: To evaluate and compare the efficacy of autologous platelet?rich plasma (aPRP) eye drop and artificial tear (AT) eye drop in moderate to severe symptomatic dry eye disease (DED). Methods: This prospective interventional study included 121 eyes of 61 patients of moderate to severe DED. Patients were divided into aPRP (31 patients) and AT (30 patients) group. Ocular Surface Disease Index (OSDI) score, tear film breakup time (TBUT) (s), corneal fluorescein staining (CFS) score, and Schirmer test score (mm) of both the groups were evaluated and compared pre?treatment and post?treatment at the end of 3 months. Results: The mean age of the aPRP group and AT group was 52.8 ± 12.8 years and 55.5 ± 13.4 years, respectively. At the end of 3 months, OSDI score reduced more in the aPRP group as compared to AT group, and the mean difference (?22.7) was statistically significant (P < 0.001). There was no significant difference in post?treatment Schirmer test score between the two groups (P = 0.44). Post?treatment improvement in TBUT and CFS score in the aPRP group was significantly higher in the aPRP group as compared to that in the AT group (P < 0.05). Bruising at the site of blood withdrawal was noted in two patients in the aPRP group. Conclusion: aPRP is safe and more effective than AT in treating patients with moderate to severe symptomatic DED
ABSTRACT
Oral carcinomas have been one of the main causes of mortality and morbidity. Tobacco chewing and cigarette smoking being the most common etiological factors management of these oral cavity cancers must take into account many factors; T1 lesions can be effectively removed using surgical removal, laser destruction or radiation therapy, while hallmark for intermediate stage oral cavity cancers is combined surgical resection with reconstruction and post-operative adjuvant radiation therapy. Treatment of these carcinomas adversely affects oral competence, ability to speech and deglutition, patient specific factors such as strong support system and patient independence must be considered, thus in this article we would review the morbidities-related post-operatively to the oral carcinomas.