Etiologic infective agents in chronic prostatis

Chronic prostatitis is a very common entity but many uncertainties exist about its etiology. In this study, 102 patients with more than 20 WBC's/HPF in EPS, and 100 controls, had their samples tested for aerobic and anaerobic organisms. 30 patients with non bacterial prostatitis and 62 controls were tested for chlamydia trachomatic antigen using ELISA. 50 patients with prostatitis and 20 controls were tested for urea plasma urealyticum. Chlamydia trachomatis was identified in the specimens of 4 [13.3%] out of 30 patients but in none of 62 controls. Additional epidemiologic data suggesting a role of chlamydia in prostatitis, as its age distribution in this study [mean of 30.2] coincided with the known age distribution of chlamydia in epididymitis where it is a well established pathogen. Mean number of WBC's/HPF in EPS was lower with chlamydia [30] than the rest of the patients [46]. This conforms with its propensity for low inflammatory response. A statistically significant difference between the patients and control groups was also found for gram negative organisms. Proteus was more frequently identified [6.8%] than E. Coli [3.9%]. Staph. albus was the most common gram positive organism [39.2%] followed by Staph. aureus [5.8%]. Anaerobic organisms and ureaplasma urealyticum were more isolated from patients than control. However, the difference is not statistically significant

Screening for chromosomal abnormalities in 78 azoospermic men

Because chromosomal abnormalities have a significant contribution to infertility in azoospermic patients, chromosomal analysis was performed in 78 azoospermic men. It was found that 20 patients [25.65%] were chromosomally abnormal

Serum gonadotropins, testosterone and prolactin in azoospermic men in relation to the histopathological changes

Serum follicle stimulating hormone [FSH], luteinizing hormone [LH], testosterone and prolactin levels in relation to histopathological appearance were studied in 32 azoospermic men. Histologically, they were classified into four groups; normal[25%], sertoli-cell-only syndrome [28.1%], maturation arrest [25%] and focal tubular atrophy [21.8%]. In azoospermic men with normal histological findings, gonadotropins and testosterone levels were within the normal values. In other groups associated with histological changes, gonadotropins were significantly raised. Testosterone had a significant lower levels than normal in cases of maturation arrest. Prolactin levels were normal in all azoospermic men. These findings suggested the importance of hormonal determination for evaluation and management of male infertility