Soft tissue reaction to bioactive glass composite blocks ossicular replacement prosthesis

Soft tissue reaction to bioactive glass composite ossicular replacement prosthesis has been evaluated in rabbits. One week after the implantation, mild inflammatory reaction was observed surrounding the prosthesis. This reaction was greatly reduced after one month and gradually replaced by a fibrous capsule without any foreign body giant cell, histiocyte or inflammatory cell infiltration. This encouraged using this material in human as ossicular replacement prosthesis with satisfactory results even without placement of a cartilage between the prosthesis and the fascia1 graft

Bioactive glass ossicular reconstruction

This study had been done for 20 patients suffering from conductive hearing loss due to ossicular discontinuity. The discs made of bioactive glass composite for ossicular reconstruction was used. Observation period ranged from 0.5-3 years during which follow up for perforations of the tympanic membrane over the implants or rejection of the prosthesis from the middle ear was done together with the audiological outcome. The study concluded that ossicular chain defects repair using the bioactive glass composite is an efficient technique with minimal morbidity and excellent results