ABSTRACT
One of the most common complications of operation and anesthesia is shivering. The purpose of this study was to compare the effectiveness of Ondanseton and Meperedine in preventing shivering after off pump coronary artery bypass graft [OPCAB]. In this double-blind randomized clinical trial, the sample consisted of 90 patients, who were candidates of CABG under general anesthesia. These patients were assigned to three groups, each containing 30 subjects: meperedine group [A], ondansetron group [B] and control group [C]. Group [A] received 0.4 mg/Kg/IV of meperedine, group [B] received 8mg/IV of ondansetron and group [C] received Normal Saline. All these drugs were injected 15 minutes before the end of surgery. After the end of surgery, the intubated patients were transferred to the ICU and their body temperature was assessed through eardrum by a specialist who was blind to the research. The incidence of shivering in groups A, B, and C was 46.48%, 31.18%, and 60.83%, respectively [P=<0.01]. The incidence of shivering was 64.4% in males and 35.6% in females [P=0.222]. Also, the amount of incidence of shivering up to 3 hours after surgery was 75.87% [P=0.064]. Bradycardia was 3.3% in group [A] and 0.0% in group [B]. Other variables [myoclonus, seizure and rash] showed no statistically significant difference [P=0.353]. According to the findings, it was demonstrated that ondansetron is more effective in preventing shivering after Off-pump CABG than meperedine
ABSTRACT
We conducted this study to compare the outcome of assisted reproductive technology [ART] procedures and recovery from anesthesia in women who received opioid analgesia with remifentanil versus fentanyl. This double-blind, randomized clinical trial was carried out in the Yazd Research and Clinical Center for Infertility, Yazd, Iran. We studied 145 women who were participants in an ART program. During the first phase of the study, all patients underwent induction of anesthesia with thiopental and received analgesia with remifentanil or fentanyl. The primary endpoint was pregnancy rate per transfer. The numbers of oocytes collected, fertilized and cleaved were recorded, as was the number of oocytes transferred and recovery profile. In the second phase of the study, all patients were followed for outcome of ART cycle. This study suggested that in women undergoing transvaginal ultrasound-guided oocyte retrieval procedures, the likelihood of a successful pregnancy was higher with a remifentanilbased monitored anesthesia care [MAC] technique than with a fentanyl-based MAC technique. The recovery from anesthesia was significantly better in the remifentanil group versus fentanyl group. The results of this study suggest that remifentanil in clinical practice is superior to fentanyl [Registeration Number: IRCT201009283468N3]