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Background: The aim was to study the role of bleomycin and doxycycline as a cheap and readily available sclero-therapeutic agent in the treatment of lymphatic malformations in paediatric populations of poor resource setting.Methods: It was a longitudinal study. A total of 23 paediatric cases with distinct types of lymphatic malformations were treated with injection sclerotherapy. Bleomycin and doxycycline used for microcystic and macrocystic lesion type respectively. The patient was followed up to complete remission. The level of evidence was Level II and type of evidence was prognosis study.Results: Commonest site of lesion was neck (78.3%), followed by cheeck (8.7%), chest, shoulder and suprapubic region. Only 21.7% of patients had good reduction (50-89%) in their lesion volume on first follow up. Overall 43.4% of patients showed a reasonable reduction in lesion volume during the follow-up period. Almost 3/4th of patients improved symptomatically on the first follow up visit. Macrocystic lesion showed an excellent response to treatment (50-89% volume reduction) in 33.3% of cases while only 16.7% of microcystic ad 12.5% of the mixed lesion showed a similar response to treatment.Conclusions: Doxycycline sclerotherapy can be a primary treatment modality in macrocystic and mixed macrocystic lesions. It is inexpensive and widely available and has minimal side effects. In contrast, bleomycine as a sclero-therapeutic agent showed an inadequate response in size reduction of microcystic lesions.
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With changing socioeconomic, demographic, and development scenario, there is a cultural shift in looking after the elderly population which may lead to depression in this age group. Materials and Methods: The study was a hospital-based cross-sectional study conducted in the orthopedic department of a tertiary care setting on 157 elderly individuals. This study was conducted with objectives to estimate the proportion of depression using the Geriatric Depression Scale Short Form (GDS-SF) questionnaire along with its associated factors in geriatric population coming to the orthopedic department of the institute. The study tools were GDS-SF, Katz Index of Independence in activities of daily living (ADL), the Lawton instrumental ADL, and health-related quality of life by the Centers for Disease Control. Results: The proportion of depressed individuals was 70/157 (44.6%) using GDS as a tool. The maximum number was in the age group of 60–74 years. Women outnumbered men (51.3% vs. 38.31%) for depression. The depression using GDS score was more prevalent in rural elderly, illiterate, and elderly who were economically dependent on their children and who belonged to lower middle socioeconomic status. Approximately 98% of the study participants were found to be independent using ADL. Approximately 60% males and 68% females were dependent for the instrumental ADL using Lawton score. Most of the study participants had arthritis as a major impairment sharing almost equal proportion among males and females. Conclusion: The current study concludes that there is a very high proportion of elderly subjects who are experiencing depression using the GDS-SF tool. There should be regular screening for this disease in this age group even in a tertiary care setting.
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Background & Objective: Self-medication is defined as medication taken on the patient own initiative or on the advice of pharmacist or any other lay person. Unavailability of qualified medical personnel in rural areas pushes the rural households for self-medication practices. The present study was conducted to elicit the self-medication pattern among rural households and its indicators across various socio-demographic parameters. Method: A cross-sectional study was conducted among 270 household. The study was carried during November 2013 to January 2014. A predesigned and pretested questionnaire was used for the study. The door to door approached was used. Out of 1500 household, 270 were sampled in this study. Statistical Analysis: Data analysis was done by using Microsoft excel 2007.Result: Medicine was available in 46.7%. Among these medicine Antibiotics was most commonly available (84.1%), followed by Antipyretics (74.6%), Analgesic (64.3%), anti-histaminic (58.7%), Multivitamin (24.6%).Fever was the most common indication (83.3%) for self-medication, followed by Body ache/Headache (51.6%). Diarrhea (53.2%), Cough (61.9%) Weakness (23.8%). In 11.1% household medicine was found expired. 77.8% of household check expiry before use medicines. Unavailability of qualified doctor (36.5%) was most common reason for self-medication. Responded were getting these medicine from medical shops either by telling symptoms (38.1%) or by using empty blister/bottle (30.2%).Conclusion: Self-medication is increasing at alarming pace. There is need to ensure community education, safety and efficacy of self-medication.
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Background: In November, 2017, the American College of Cardiology (ACC) and American Heart Association (AHA) released new guidelines for classification of hypertension among adults. JNC 7 guidelines are most used till now. The present study aimed to measure the burden of hypertension among adult population using new ACC/AHA guidelines and to compare it with JNC 7. Method: A descriptive cross sectional study was carried over a period of one month as a part of MBBS student project. Blood pressure of hospital visitors/attendants was measured using Omron HEM-8711 blood pressure monitor with standard technique. A total of 437 participants were got measured their blood pressure. Result: 31.6% of participants self-reported their hypertensive state. Out of 299 participants who were now aware about their blood pressure status, 55% labelled as hypertensive using new ACC/AHA guidelines as compared to only 22% with earlier JNC 7 guidelines.
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Our study on 106 cases of bone tumors aims at correlating the clinical, radiological and cytological findings of benign and malignant tumors of bone and evaluating the usefulness of percutaneous biopsy as a diagnostic tool in underdeveloped countries. Giant cell lesions were the most common benign tumor, 42 cases (84%) and giant cell tumor was the most common giant cell lesion in our study, 27 (64.3%). Round cell tumor appeared to be the most common malignant tumor of bone, 20 cases (35.7%). Osteosarcoma represented 15 cases (14.2%) of all bone tumors and 26.8% of all malignant bone tumors in our study. Final histopathological diagnosis was available only in 54 cases. Out of which 53 cases showed concordance with previous cytological diagnosis. Only a single case of chondrosarcoma was misdiagnosed as chondroma on FNAC (false negative). The sensitivity and specificity of FNAC was 96.0% and 100% respectively while positive predictive value and negative predictive values were 100% and 96.7% respectively. The diagnostic accuracy in our study was 98.1%.
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Glomus tumours are usually benign neoplasms of glomus bodies. Here we report a rare case of malignant glomus tumour of soft tissue. The tumour was 8 cm in size, infiltrating deep tissue, with nuclear atypia, high mitotic activity (6/HPF), atypical mitosis and showed recurrence, thus fulfilling all the criteria of malignancy.
Subject(s)
Adult , Elbow , Female , Glomus Tumor/diagnosis , Histocytochemistry , Humans , Soft Tissue Neoplasms/diagnosisABSTRACT
Serum IgG, IgA and IgM were estimated in 42 cases of carcinoma and 12 cases of fibroadenoma of breast. The results were compared with 20 healthy female controls. Results showed increased levels of serum IgA in carcinoma breast cases. This increase was statistically significant (p = 0.001) when compared with healthy controls while IgG and IgM values were found to be insignificant. Values of IgG, IgA and IgM in cases of fibroadenoma breast when compared with the controls were found to be insignificant. Statistically significant increased value of IgA was also observed in medullary carcinoma and non-metastasizing tumours when viewed separately, suggestive of good prognostic index of serum IgA level estimation in the case of carcinoma breast.