Maximizing resection of diffused low-grade glioma functional outcome

Background: most of adults with Diffuse Low Grade Gliomas [DLGGs] are diagnosed with an average age of 39 years and the diagnosis is often made around fully functioning individuals. Currently extent of resection [EOR] is a generally known variable that impacts overall survival [OS], progression free survival and malignant transformation in these gliomas

Aim of the study: This study aimed to evaluate the risks and benefits of maximizing the extent of resection of DLGGS, while preserving neurological function

Methodology and Materials: this was a prospective observational study of group of consecutive 20 patients with initial imaging diagnosis of supratentorial DLGGs. Preoperatively planned for maximal resection even if presuming the proximity of these lesions to eloquent cortex and their relative diffuse nature on imaging

Results: 40 % were near eloquent area and 30 % at eloquent areas. GTR achieved in 10% and STR in 65%. Pre-operative Karnofsky Performance Scale [KPS] was 100 in 10%, 90 in 65%, 72 hours post-operative 70 in 60%. During the first 6 months of follow-up KPS was 100 in 60% of the study cohort while only one patient [5%] died. After 6 months KPS was 100 and represented 95% of the whole study. LOS was the longest [4-16 days] in near eloquent and shortest in eloquent [5-8 days]. 30% had pre-operative uncontrolled seizures, which cured post-operative, 50% stopped AED within a year. Average back to work period was 2.5 for eloquent, near eloquent 2.8 and non-eloquent 2.6 months

Conclusion: careful pre-surgical planning based on proper reviewed history, recent imaging techniques and utilizing up-to-date intra-operative technology is helping to maximize safe surgical resection, while saving patient function and quality of life

Immunological Role of Nasal Staphylococcus aureus Carriage in Patients with Persistent at Allergic Rhinitis

Nasal carriage of staphylococcus aureus (S.aureus) exerts immunomodulatory effect in patients with atopic dermatitis and it may contribute to airway inflammation and allergic response in patients with allergic rhinitis. We Aim to investigate the frequency of nasal S.aureus carriage in patients with persistent allergic rhinitis and its possible influence on their symptoms and immune markers. We chosed 20 non smoker patients with house dust mite (HDM) allergy causing allergic rhinitis and 20 non smoker healthy subjects matched for age and sex. For all subjects rhinoscopy was done; skin prick test; nasal culture for S.aureus; nasal interleukin 4;nasal total IgE; serum total IgE and serum specific IgE(SSIgE) for HDM. Nasal S.aureus was detected in 16/20 patients (80) and 5/20 (25) in healthy subjects with highly significant statistical difference p0.01. Correlation of nasal staph.aureus count and different systemic and local immune markers revealed highly significant positive correlation between nasal S.aureus count and serum total IgE (r

Immunological Role of Nasal Staphylococcus aureus Carriage in Patients with Persistent at Allergic Rhinitis

Nasal carriage of staphylococcus aureus (S.aureus) exerts immunomodulatory effect in patients with atopic dermatitis and it may contribute to airway inflammation and allergic response in patients with allergic rhinitis. We Aim to investigate the frequency of nasal S.aureus carriage in patients with persistent allergic rhinitis and its possible influence on their symptoms and immune markers. We chosed 20 non smoker patients with house dust mite (HDM) allergy causing allergic rhinitis and 20 non smoker healthy subjects matched for age and sex. For all subjects rhinoscopy was done; skin prick test; nasal culture for S.aureus; nasal interleukin 4;nasal total IgE; serum total IgE and serum specific IgE(SSIgE) for HDM. Nasal S.aureus was detected in 16/20 patients (80) and 5/20 (25) in healthy subjects with highly significant statistical difference p0.01. Correlation of nasal staph.aureus count and different systemic and local immune markers revealed highly significant positive correlation between nasal S.aureus count and serum total IgE (r

Rhipicephalus sanguineus tick allergy in asthmatic patients; diagnosis and immunotheraputic trial

Ticks belonging to the superfamily Ixodiodea have a potential role in allergic diseases including atopic skin diseases and atopic asthma. Tick extracts or vaccines were not prepared before, nor used in diagnosis or in specific immunotherapy of allergic patients. Therefore this study was carried out to diagnose and differentiate ticks allergy in asthmatic patients and to valuate the role of specific immunotherapy in those patients. The study included fourty patients with bronchial asthma and twenty healthy control persons. Patients were examined and classified according to their clinical staging [respiratory function test, presence of day time symptoms, exacerbations and presence of night time symptoms]. All subjects were investigated by skin prick test serum specific Ig E level, blood eosinophils and basophils phagocytic function test, lymphocytic population test and Immunogram including serum Ig M, and Ig G levels. After diagnosis of tick allergy by perivous investigations tick allergic patients were subjected to specific immunotherapy by tick vaccine using conventional updosing protocol by subcutaneous injection route and reevaluated both clinically and laboratory. Diagnosis of tick allergy was demonstrated by positive skin test and by highly significant statistical difference [P < 0.01] between patients and control group as regard the serum specific Ig E using tick extract. After immunotherapy the patients were clinicaly improved with highly statistical difference [P < 0.01] than before specific immunotherapy. Also, there were highly significant decrease [P < 0.01] in eosinophils count, basophils count, serum specific Ig E for tick allergen, and Ig M level while there were significant [P < 0.05] increase in phagocytic function test, lymphocytic populations test and Ig G level. Tick allergy was differentiated in Egyptian asthmatics and tick specific immunotherapy is highly successful in their management

Study of fit, microleakage and shear bond strength of CAD-CAM fabricated porcelain laminate

The aim of this work was to evaluate the Cerec 1, Cerce 2 and the conventional porcelain laminate veneers in terms of fit, microleakage and shear bond strength to the tooth surface. Thirty maxillary central incisors were used for the fit and microleakage tests. They received standardized preparations and were divided into three groups of ten each. Group 1, 2 and 3 were restored with Cerec 1 Cerce 2, and conventional laminate veneers respectively. Alter staining and thermocycling, the teeth with their bonded laminates were sectioned by two cuts [incisogingivally and misiodistally]. Fit and microleakage were evaluated by measuring the cement thickness and degree of dye penetration respectively using an image processing computerized stereomicroscope. For the assessment shear bond strength thirty other central incisors received flat preparations in enamel. Thirty porcelain specimens were fabricated using the above systems [ten specimens each] then bonded to the prepared enamel surface. After themocycling, a shear test was done using a universal testing machine. The debonded surface were then observed under a scanning electron microscope. Overall, the Cerec 2 CAD-CAM laminate veneers did overcome many of the disadvantages found in the Cerec 1 laminate veneers. The quality of the laminate veneers produced by the Cerec 2 CAD-Cam unit is comparable to the conventional laminate veneers

Effect of repeated immobilization on musculoskeletal system and parathyroid hormone in male albino rats

In this study, 40 adult male albino rats were used to investigate the effect of repeated immobilization stress on the musculoskeletal system and parathyroid hormone. The rats were divided into two equal groups [control and experimental]. The rats of the control group were kept in the housing cages, while those of the experimental group were put singly in cages 10 x 5 x 5 cm for six hours daily, then returned to the housing cages. This procedure was continued for 15 days. At the end of the experiment, blood was taken to estimate serum calcium, phosphorus, alkaline phosphatase and parathyroid hormone. Specimens from skeletal muscles, long bones and joints were taken for a histological examination

Age-related response to noise stress on gastric secretion and ulceration in male albino rats

The effects of noise on gastric secretion and ulceration in male albino rats were investigated. Forty-eight rats were used and divided into three main groups i.e. young, adult and senile. Each group was subdivided into control and experimental subgroups. The experimental animals were exposed to noise stress [100 dB] one hour daily for four weeks. The results showed that noise decreased the volume and total acid output in all animal groups and increased the titratable acidity in young group. Noise increased the ulcer index in adult and senile groups and led to vascular congestion, inflammatory cell infiltration, glandular deformity, mucosal atrophy and musculosa hypertrophy in the stomach of all groups

Effect of unsatisfied sexual excitation on reproductive system in male albino rats

Sixty adult albino rats [20 males and 40 females] were used to study the effect of sexual excitation on the male genital system. Rats were divided into two equal groups i.e. control and experimental. Rats were exposed to continuous sexual excitation for one month. Hormonal studies showed imbalance in the pituitary gonadotrophic and corticotrophic hormones as well as testosterone and cortisol. Histological studies showed severe affection of the secretory sex organs [testes, seminal vesicles and prostate] with no significant affection of the penis and vas deference

Experimental study of the effect of using different agents on the oral health condition of diabetic patients in mansoura city

A random sample of 100 female controlled diabetic patients was selected and divided into four groups [25 women each]. Three groups constituted the experimental subjects using the oral hygiene selected agents [tooth brushing with toothpaste, warm saline with glycerin and chlorhexidine] and the fourth group constituted the control subjects. The results revealed a significant improvement of diabetic patients oral health practice as well as relieved their oral health problems after program intervention particularly with using regular oral cleanliness plus warm saline and glycerin, this was followed by the chlorhexidine group