A Single Centre Open Label Non-Randomized Phase-IV Post Marketing Surveillance Study to Evaluate the Efficacy and Safety of Roop Mantra Ayurvedic Medicinal Cream

Objectives: The objective of the study was to evaluate the efficacy and safety of a polyherbal Roop Mantra Ayurvedic Medicinal Cream in subjects with acne, facial scars, pimples, blemishes, dull and dry skin. Methods: This was a 60-day, single-centre, open-labelled, non-randomized phase-IV surveillance study with 120 subjects. Subjects were selected based on the study's inclusion criteria. The study included three scheduled clinical visits on days 0 (screening and baseline visit), 30 (follow-up visit), and 60 (final visit). Following an evaluation of baseline data, all subjects were given Roop Mantra Ayurvedic Medicinal Cream for 60 days. The primary outcome of the study was to assess the efficacy of Roop Mantra Ayurvedic Medicinal Cream based on changes in parameters such as skin texture, skin health, global acne assessment parameters and an investigator assessment scale. The secondary outcome of the study was the determination of local intolerance and adverse effects to Roop Mantra Ayurvedic Medicinal Cream . Results: The study findings revealed that the use of Roop Mantra Ayurvedic Medicinal Cream for 60 days improved skin texture and appearance while significantly reducing acne, pimples, blemishes, and skin dryness. Roop Mantra Ayurvedic Medicinal Cream was likewise dermatologically well tolerated and did not cause any adverse effects during the study period. Conclusion: Roop Mantra Ayurvedic Medicinal Cream showed highly satisfactory results in terms of skin texture, skin appearance and general acne parameters without having any adverse effects on the skin. Given the positive outcomes, Roop Mantra Ayurvedic Medicinal Cream is clinically effective and safe alternative for treating various skin problems.

A Single Centre Open Label Post Marketing Surveillance Study to Evaluate the Efficacy and Safety of Roop Mantra Cucumber Ayurvedic Medicinal Face Wash

The objective of the study was to assess the safety and efficacy of Roop Mantra Cucumber Ayurvedic Medicinal Face Wash in subjects with acne, facial scars, pimples, blemishes, dull skin and dry skin. Methods: This was a single-center, open-label, non-randomized post-marketing surveillance study with 120 subjects. Subjects were selected on the basis of inclusion criteria. The study included three scheduled clinical visits on days 0 (screening and baseline visit), 15 (follow-up visit), and 30 (final visit). Following an assessment of baseline data, all subjects were given Roop Mantra Cucumber Ayurvedic Medicinal Face Wash for 30 days. The efficacy of Roop Matra Cucumber Ayurvedic Medicinal Face Wash was determined by measuring changes in parameters such as skin characteristics, skin appearance, and Global Acne Assessment (GAA) score. Product safety was assessed by determining local intolerance and adverse effects of Roop Mantra Cucumber Ayurvedic Medicinal Face Wash. Results: The results of the study showed that applying Roop Mantra Cucumber Ayurvedic Medicinal Face Wash for 30 days significantly improved skin’s characteristic and appearance. Roop Mantra Cucumber Ayurvedic Medicinal Face Wash was also found to be dermatologically well tolerated and had no negative impacts over the course of the study. Conclusion: The polyherbal Roop Mantra Cucumber Ayurvedic Medicinal Face Wash was found to be very safe and effective in reducing acne, pimples, blemishes, and skin dryness with improved skin texture and appearance. Roop Mantra Cucumber Ayurvedic Medicinal Face Wash is therefore a clinically feasible and safe alternative for treating the aforementioned skin conditions.

Risk Factors for Major Adverse Cardiac Events Outcomes in Post Percutaneous Coronary Intervention during Index Admission

@#Introduction: Patients with ST-segment elevation myocardial infarction (STEMI) often undergo percutaneous coronary intervention (PCI) procedures during their index hospitalisation. However, some factors may increase the risk of major adverse cardiac event (MACE) outcomes after delaying PCI. We aimed to determine the risk factors for MACE outcomes in acute STEMI patients who had PCI during their index admission. Methods: In this retrospective single-center study, the medical records of STEMI patients who had PCI during their index hospitalisation in our facility were retrieved. At 30 days and six months post-PCI, demographic characteristics, clinical presentation, coronary risk factors, and the rate of MACE outcome were recorded and analysed. Results: This study included 91 STEMI patients. At 30 days and six months post-PCI, the rate of MACE was 10.5% and 8.0% respectively. At 30 days post-PCI, gender (p = 0.025), systolic blood pressure (p = 0.005) and heart rate (p = 0.003) were all associated with MACE outcomes. At six months, systolic blood pressure (p = 0.017), heart rate (p = 0.003), and previous coronary artery disease (CAD) (p = 0.014) were all associated with MACE. Conclusion: In acute STEMI patients, female gender, systolic blood pressure, heart rate, and a history of CAD are the risk factors for MACE outcomes after the PCI during the index admission. However, this is only single center study with short follow up period. Therefore, multi centers study and longer follow up period could provide better understanding on the factors associated with delayed PCI.

Prosthetic rehabilitation of maxillectomy patient with telescopic dentures

This article describes a technique of management of maxillectomy defect with a complex partial denture in a 33 years old male patient. The purpose of this treatment was to improve the retention and stability of the prosthesis. A telescopic denture was fabricated to rehabilitate the maxillectomy defect. Telescopic removable partial dentures may be considered as an alternative option, combining good retentive and stabilizing properties. With telescopic dentures, the insertion and removal is much easier for the patient. The aesthetic enhancement and functional rigidity provided by telescopic retainers are favourable features to many challenging clinical situations. Telescopic denture has the benefit of secure attachment and increased bearer confidence

Chronic suppurative otitis media: disease pattern and drug sensitivity

To identify the frequency of bacterial isolates associated with chronic suppurative otitis media [CSOM] and to determine their antibiotic sensitivity pattern. Descriptive study. Department of E.N.T, Jinnah Medical and Dental College Hospital, Korangi Karachi, from April 2003 to June 2005. Two hundred patients of CSOM were included in this study. Ear swabs were taken from these patients and cultured on chocolate and blood agar. Antibiotic sensitivity was determined by disc diffusion method using Muller Hinton agar. Biochemical tests were used in identifying gram-negative bacteria. From 200 ear swabs different micro-organisms were isolated. The bacteria isolated were Pseudomonas aeruginosa in 83 cases, Staphylococcus aureus in 38 patients, Proteus mirabilis in 36, Klebsiella pneumoniae in 21, Escherichia coli in 8, beta haemolytic Streptococcus in 10 and Serratia species in 4 patients. Most of the bacterial isolates were resistant to common antibiotics but they were sensitive to ofloxocin [92.2%], ciprofloxocin [92.2%], amikacin [90%], gentamycin [88.4%], ceftazidime [86.4], ceftriaxone [70.4%], polymyxin B [70%], amoxicillin clav.[40%], ampicillin [10%], cephradine [10%] erythromycin [6%].In CSOM, high rate of multiple drug resistance specially to frequently used antibiotics has risen

Patterns of implant failure in idiopathic scoliosis fixed with transpedicular screws

Transpedicular screw failure with new segmental fixation was described in the literature with a varying incidences in degenerative lumbar conditions, spondylolisthesis and fractures of dorsal and lumbar spine,3'4'5'6'7 but little, if any, was written on this subject regarding scoliosis. May be because till recently FDA did not yet approve its use in scoliosis. The aim of this study was to detect the patterns of implant failure in idiopathic adolescent scoliosis with different types of transpedicular screw fixation and the possible factors that may be responsible for such pattern of failure. Material and methods: 69 cases of idiopathic scoliosis of more than 3 years follow up were examined. Sixteen cases had shown 21 screws failure. The patients included 15 girls and one boy. The average age was 13.06 years The systems used for fixation in those cases of implant failure were TSRH in 7 cases, Claris in 8 cases and Isola in one case. Main results Claris system had the highest incidence of implant failure [38.1%] followed by TSRH [28%] and the least was Isola system [4.3%]. The average number of screws and number of vertebrae fixed with the three system were nearly equal. The main mode of failure with Claris system was due to looseness of the connector screw interface that occurred in 70% of cases. This mode of failure represented 50% of cases with TSRH while the other modes were pulling out of the screw [30%] and screw breakage [20%]. The failed case in Isola system was due to looseness of the screw connector interface. The Lower end of the curve contains two thirds of the cases of failure and the main mode of failure in this area was due to looseness of the connector screw interface [71.4%]. In the upper end of curve failure occurs mainly due to pulling out of the screws. The main modes of failure, however, in the intermediate portion of the curve were both pulling out and looseness of the connector. The mode of failure did not show evident change with the two methods of curve correction [Cephalo-caudal compression-distraction and derotation]. Also the mean percent of correction of the curve was not different in the different mode of failures