ABSTRACT
Introduction: Atherosclerosis is a systemic disorder that often involves multiple arterial beds such as carotid, coronary and peripheral arteries. The progressive simultaneous increase in the degree of carotid artery stenosis [CAS] with CAD [Coronary Artery Disease] has raised the valid speculations of a same mechanism of stenosis in both the arterial fields
Objective: The objective of this study was to correlate CAS severity with CAD severity by comparing Ultrasound measurements of CAS in study group subjects with evidence of significant CAD on coronary angiography and control group subjects with normal coronaries or non-significant CAD coronary angiography
Methodology: This case control study was conducted at Cardiology Department/Punjab Institute of Cardiology Lahore, Punjab, Pakistan from 1/2/2016 to 30/7/2016. In this study the Non Probability consecutive sampling technique was used. The Sample size was 86 with 43 case and 43 control population
Results: The average age of the patients was 53.45+/-10.16 years. The female to male ratio was 1:1.9. In this study 46 percent had normal carotid arteries with no evidence of atherosclerotic plaque. Clinically significant Carotid artery stenosis [>50 percent] was found in 0 percent of patients with normal coronaries and in 4.3 percent of patients with non-significant CAD. Similarly, clinically significant CAS was found in 10 percent, 20 percent, 50 percent, and 45.5 percent of patients with 1 VD, 2 VD, 3 VD and LMD, respectively. In this study there was the positive correlation between the CAS and CAD severity while comparing cases and control groups
Conclusion: The principle result of this study is that the degree of carotid artery disease is positively correlated to the severity of CAD
ABSTRACT
Objectives: To evaluate the effect of half adult dose of oral Rifampicin on mean change in best corrected visual acuity and central macular thickness in patients with central serous chorioretinopathy
Methods:Thirty-eight eyes of 31 patients with idiopathic central serous chorioretinopathy [CSCR] were registered. Unaided Visual acuity, best corrected visual acuity was documented and detailed slit lamp examination along with dilated ophthalmoscopy was performed. All subjects were treated with oral Rifampicin 300 mg [half adult dose] daily for 03 months. Patients underwent a complete ocular and systemic examination as well as central macular thickness [CMT] measurement by optical coherence tomography [OCT] every month after starting treatment until four months. Fundus fluorescein angiography [FFA] was performed in recurrent cases. Liver function tests were carried out prior to the treatment and during follow up period
Results:A total of 38 eyes of 31 patients [24 males, 07 females] were included in the study. Mean age of patients was 36.16+/-3.19 years [range 30-44]. Mean best corrected visual acuity [BCVA] before treatment was 0.56+/-0.11 and improved to 0.47+/-0.14 at 04 weeks [P<0.001] of treatment. The mean CMT at the time of presentation was 494.39+/-96.29 um and was decreased to 306.90+/-50.71 um after 04 weeks of treatment [P<0.001]. The mean induced reduction in CMT was 187.48+/-122 um [P<0.001] while that in BCVA 0.41+/-0.16 at 04 weeks of treatment [P<0.001]. Liver function tests were within normal range before and after the treatment
Conclusion:Half adult dose rifampicin [300mg] is effective and safe in treatment of central serous chorioretinopathy without causing any systemic imbalance