ABSTRACT
The incidence of local recurrence [LR] following curative surgery for rectal cancer has been reported to range from 10 to 60%. Recently, data from several clinical trials have suggested that LR can be reduced by op to 40% with pre-operative radiotherapy and even further if combined with chemoradiotherapy. Seventeen patients were included in the study; all had adenocarcinorria of the rectum. Sphincter-preserving surgery could be achieved in 11 of the patients [64.7%] while the remaining 6 [35.3%] had abdomino-perineal resection [APR].Pathologic staging after preoperative combined modality therapy for the 17 patients who underwent radical surgery was: Tl-4 NO-2 MO. The incidence of failure was as follows: local, 5.8 % [1/17]; abdominal, 11.7% [2/17]; and distant, 17.6% [3/17].Treatment with preoperafive combined modality therapy followed by surgery and postoperative 5-FU based chemotherapy is an alternative to postoperative combined modality therapy for patients with rectal cancer.Purpose: To determine the local control rale and acute ioxicity in patients with clinically resectable adenocarcinoma of therectum treated with preoperative combined modality therapy
ABSTRACT
Duplex sonography, combining B-mode imaging and doppler spectrum analysis, has been proved to be an accurate and effective means of detecting and assessing carotid occlusive disease. High resolution imaging allows assessment of the risk of embolism through plaque characterization, while image and doppler spectrum analysis provide quantification of flow characteristics to determine the degree of stenotic flow restriction