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Indian J Physiol Pharmacol ; 1997 Jul; 41(3): 234-40
Article in English | IMSEAR | ID: sea-107413

ABSTRACT

Oral administration of 20, 40, 60, mg of dry Azadirachta indica leaf powder for 24 days resulted in decrease in the weights of seminal vesicles and ventral prostate, reduction in epithelial height, nuclear diameter and the secretory material in the lumen. Biochemically, there was a decrease in total protein, acid phosphatase activities. Seminal vesicles and ventral prostate being androgen dependent, the regressive changes histologically as well as biochemically, suggests the antiandrogenic property of the neem leaves.


Subject(s)
Acid Phosphatase/metabolism , Administration, Oral , Alkaline Phosphatase/metabolism , Animals , Glucose/metabolism , L-Lactate Dehydrogenase/metabolism , Male , Plant Leaves/chemistry , Plants, Medicinal , Powders/pharmacology , Prostate/cytology , Rats , Seminal Vesicles/cytology
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