Randomized controlled trial comparing pregnancy outcome using artificial versus letrozole stimulated cycle in cryo preserved embryo transfer

Background: Intracytoplasmic sperm injection [ICSI] is a procedure performed in the IVF embryo laboratory after the eggs have been retrieved from the ovaries and involves placing a single sperm directly inside the egg. It is indicated for cases which involve very low sperm counts or motility

Aim of the Work: To compare the outcome of pregnancy using artificial and letrozol stimulated cycle in cryo preserved embryo transfer

Patients and Methods: This randomized controlled trial was conducted on 190 patients attending the clinic submitted for embryo transfer of cryo embryos. All cycles were performed at international Islamic Center for population Studies and Research Assisted Reproduction Unit [ART unit IICPSR] at Al-Azhar University and evidence based centers

Results: Pregnancy rate was significantly higher in letrozole [53.2%] compared to the artificial group [40.6%]. Furthermore, first trimester abortion rate was non-significantly lower in letrozole group

Conclusion: ovulation induction with letrozole during endometrial preparation for cryopreserved ET has a significantly higher ongoing pregnancy rate than artificial cycle. The reported ongoing pregnancy rate in letrozole arm was encouraging and may provide an alternative mean to artificial cycles in endometrial preparation in FET

Serum leptin level in type 1 diabetes mellitus

Diabetes mellitus is the most common endocrine metabolic disorder of childhood. Leptin a hormone produced by adipocytes is essential for proper growth and development. Acting primarily on the hypothalamus, and has effects on appetite, energy expenditure and the neuroendocrine axis. The present study was designed to estimate serum leptin levels in type 1 diabetes mellitus and its correlation to age, sex, growth and BMI. The study was conducted on 20 patients [8 males and 12 females] with IDDM and 10 healthy children as control group [8 males and 2 females]. They were subjected to full history taking, clinical examination, assessment of weight, height, and BMI Serum leptin was measured by ELISA technique, Fasting, and two hours post prandial Blood glucose and serum insulin level were measured. Our results show: serum leptin level was insingnificantly lower in males than females, there was significant positive correlations between leptin level and body weight and BMI. positive correlation between serum leptin and serum insulin levels. But no significant correlations was found between serum leptin and Blood glucose level