ABSTRACT
The main objective of the present work was to develop sustained release matrix tablets of Atenolol. To reduce the frequency of administration and to improve the patient compliance, a once daily sustained release formulation of Atenolol is desirable. So sustained release Matrix Tablet of Atenolol was designed by using different polymers viz.Starch, Xanthan Gum, Vee Gum , Guar Gum, Gum Accacia, Tragacanth, Hupu Gum were used as natural polymers and Eudragit-L100, Ethyl Cellulose, Sodium Carboxy Methyl Cellulose (Na-CMC) ,Hydroxy Propyl Methyl Cellulose (HPMC) (5&15cps), Methyl Cellulose, Kollidon were used as synthetic polymers. After fixing the ratio of drug and polymer for control the release of drug up to desired time, the release rates were modulated by Single polymer, combination of two different rates controlling material. The FT-IR study revealed that there was no chemical interaction between drug and excipients. The granules were prepared by dry granulation method. Precompressional parameters i.e. angle of repose, percent compressibility, and Hausner’s ratios were studied. These results indicate that granules are good flowing characteristics. After evaluation of physical properties like Weight variation, Hardness, Thickness, Friability of tablet, the different formulations checked for the Percentage Drug content which having good uniformity. The results of drug dissolution studies showed improved drug release, retardation effects of the polymers and could achieve better performance. After eight hours dissolution test, dissolution profiles showed that better sustained release was observed from starch and veegum containing formulation and eudragit and ethyl cellulose containing formulation of atenolol matrix tablet. It was also observed that the presence of starch caused an increase in the release rate of atenolol matrix tablet. The present study shows a relatively simple method to design and develop Atenolol matrix tablet.
ABSTRACT
The study was aimed to investigate the effect of polymer on the release profile of Naproxen from different percentages of HPMC 5cps and Kollidon SR based matrix systems. Different amount of HPMC and Kollidon SR were used to develop matrix builder in the four proposed formulations (F1-F4) for the study of release rate retardant effect at 25% and 35% of total weight of tablet matrix respectively. The tablets were prepared by direct compression method. The granules and tablets were evaluated for their physical properties and they did not show any significant variations and were found to have good physical integrity. The dissolution study of those proposed formulations were carried out in the simulated intestinal medium (pH 7.4) for 8 hours using USP paddle method with 50 rpm at 37±0.5⁰C. HPMC is hydrophilic and Kollidon SR is hydrophobic in nature. Statistically significant difference were found among the drug release profile from different percent of polymer and the release mechanisms were explored and explained with zero order, Higuchi and Korsmeyer equations. The release of Naproxen from F-1 and F-2 very closely followed Korsmeyer release kinetics where F-3 and F-4 best fitted with Higuchi model. The cumulative percent release of Naproxen was highest in F-2 containing 35% of HPMC. On the basis of results, it was found that the profile of F-1 formulation was the best among the four formulations. Between these two polymers, HPMC showed better percentage of release and Kollidon SR showed better release retardant effect.