ABSTRACT
Background: The improvement in the survival rate from cancer is increased due to advancement in the early detection, combined modality therapy and right therapeutic strategies. This study was aimed to assess the survival outcomes of patients diagnosed with non-small cell lung cancer (NSCLC) at King Abdulaziz University Hospital (KAUH).Methods: This retrospective cohort study included all patients aged 14 years and older with a diagnosis of NSCLC from 2007 to 2017 using electronic medical records at KAUH. Data analysis was performed by using Stata SE, version 15.0. Survival was defined as the time the patient lived in months from the date of pathological diagnosis to the date of last follow-up or death. All variables in a univariate and multivariate analysis were included.Results: Adenocarcinoma was the most common type of NSCLC observed in both genders, accounting for 43.70% of all cases. Of the patients diagnosed with NSCLC the overall median survival was 12.2 months (interval=16.9). And among all variables, surgical treatment was associated with a 71% relative reduction in risk of death (hazard ratio 0.29, p<0.014), and chemotherapy a 57% relative reduction in risk of death (hazard ratio 0.43, p<0.013).Conclusions: The median age of diagnosis of NSCLC in Kingdom of Saudi Arabia (KSA) was younger than United States of America, this could be due to many factors including smoking. The number of lung cancer cases among women was lower than men.
ABSTRACT
To assess the prevalence of epidemiologically defined chronic obstructive pulmonary disease [COPD] in Saudi Arabia. This cross-sectional, observational, population-based survey of COPD was conducted between June 2010 and December 2011 across the country of Saudi Arabia. A total of 56,000 randomly selected telephone numbers were called, which identified 10,001 eligible subjects; of whom 9,779 agreed to participate. A screening questionnaire included 6 questions related to cigarette consumption and water-pipe use was administered to each participant. Subjects with positive screening results were invited to provide input for a detailed COPD questionnaire. The adjusted proportion of subjects who reported a current, or past smoking history was 27.9%. Gender specific smoking rates adjusted by age were 38.7% [95% confidence interval [CI]: 37.5-39.9%] in men, and 7.4% [95% CI: 6.5-8.3%] in women. The epidemiological definition of symptomatic COPD was met by a total of 249 subjects. The age and gender-adjusted prevalence of COPD was 2.4% [95% CI: 2.1-2.7%]. Overall, COPD was more frequently documented [p<0.0001] in men [3.5% [95% CI: 3-4%]] than in women [1% [95% CI: 0.7-1.3%]]. The prevalence of epidemiologically defined COPD in the general population of Saudi Arabia is 2.4%, which is lower than that reported in industrialized countries