ABSTRACT
One hundred strains of C. albicans from different clinical and environmental sources were tested to evaluate their sensitivity to some antibacterial and antifungal agents [tetracycline, chloramphenicol, miconazole and nystatin and their combinations in pairs]. Tetracycline and chloramphenicol and combination of both drugs had no inhibitory effect on the growth of all isolates of C. albicans tested at maximum concentration [20 ug/ml]. However, tetracycline, but not chloramphenicol, was found to enhance the growth of C. albicans. C. albicans was sensitive to nystatin [MIC 12.5 to 100 ug/ml], but highly sensitive to MCZ [MIC 0.005 to 50 ug/ml]. Combination of antifungals and antibiotics tested exerted synergistic activity against all isolates of C. albicans in different concentration. For instance MCZ with tetracycline [MIC 0.005 to 12.5 ug/ml], MCZ with chloramphenicol [MIC 0.005 to 25 ug/ml], combination of nystatin with tetracycline [MIC 78 to 100 ug/ml] and nystatin with chloramphenicol [MIC 6.25 to 100 ug/ml]. The pathogenic isolates of C. albicans were more resistant than nonpathogenic and environmental isolates to antifungal and their combinations with antibacterial antibiotics used