ABSTRACT
Atracurium besylate is used mainly to produce skeletal muscle relaxation during surgery and to increase pulmonary compliance during assisted or controlled respiration [ventilation] after general anesthesia, also been used to facilitate endotracheal intubation. Fetal [Baby] wellbeing depends on placental blood flow which affected by systemic hypotension or hypertension, uterine blood flow rate which affected by maternal hemodynamic, uterine contraction and drugs that pass the placental blood barrier. Eighty pregnant women with full term pregnancy, normotensive, non diabetic or hypertensive [essential, pregnancy induced hypertension or eclampsia] and without any medical problems within normal placental sit and function undergoing Caesarean Section were included in this study. They had ASA grade I, their age ranged between 22-45 years old, their body weight was between 60-80 kilograms and received general anesthesia, half an hour to one hour after premedications [Primperan 10 mg IV, Randitine 100-150mg and 30 ml of 0.3-m sodium citrate [22], all patients had pre-oxygenation for 5 minutes and anesthesia induction was with intravenous sodium thiopentone [2.5%] 4mg/kg, scoline 1mg/kg, Atracurium 1-1.5mg/kg just after cndotracheal intubation and anesthesia was maintained by inhalational agent isoflurane 0.5%, Apgar score and baby's wellbeing were assessed in all the babies at the end of 1st and 5th minutes respectively. Resuscitation measures were also noted by pediatrician, data expressed as mean, standard deviation. A P-value<0.05 was considered statistically significant. After analysis of the collected data, there were no clinical significant decrease in maternal hemodynamic or babies wellbeing detected but statistically is highly significant as "t" test and P-value was 0.000, also baby's wellbeing was normal but Apgar Score and umbilical venous pH find a statistically significant-value 0.000. The administration of neuromuscular blocking agents [Atracurium] during Cesarean Section has no immediate or delayed adverse effects on the fetus, does not increases the likelihood of resuscitation the neonate. Indeed, the maternal hemodynamic changes in this study neither affects the placental blood flow and it's blood pressure auto-regulation range nor the babies wellbeing