Biochemical and histopathological studies on the effect of some pesticides on pancreas of male rats

The effects of two classes of insecticides were studied on the pancreas of male rats through an evaluation of blood Sugar level and serum amylase activity. Carbamate thiodicarb, represented by larvin in a single or repeated doses produced hyperglycemia, and showed a significant increase in the amylase activity. The synthetic pyrethroid cypermethrin produce hyperglycemia after single dose, while repeated dose produce hypoglycemia. The amylase activity is significantly increased by single dose only, while repeated dose had no effect. This biochemical data was confirmed by histopathological changes in the pancreatic tissue, suggesting that these insecticides have a diabetogenic effect

Toxicological effects of pirimiphos-methyl and deltamethrin on albino rats

Multi-dose effect of pirimiphos-methyl and deltamethrin on some blood parameters, liver protein content, blood glucose, cholinesterase glutamic oxaloacetic transaminase, glutamic pyruvic transaminase were studied at sub-lethal doses [0.1 LD50 and 0.25 LD50]. The obtained data domenstrated that total leukocytes were significantly increased, with the exception in case of pirimiphos-methyl at 0.1 LD50, but the other blood parameters were not affected. Liver protein and blood sugar were affected apparently after exposure to deltamethrin. The biochemical data showed significant inhibition of cholinesterase activity after exposure to pirimophos-methyl, on the other hand, deltamethrin has no effect, Glutamic oxaloacetic and glutemic pyruvic transaminase activities were markedly increased due to the insecticides treatment