ABSTRACT
The ability to taste Phenylthiocarbamide [PTC], a bitter organic compound, described as a bimodal autosomal trait is widely used to know the heritable trait in both genetic and anthropological studies. The present study was carried out to analyze the prevalence of PTC taste sensitivity and to determine the gene frequencies among some Muslim populations of Uttar Pradesh, India. This study has some physiological relevance to highlight the adapt-ability of endogamous groups to behavioral traits in the same place. Unrelated, healthy individuals of both sexes [Male-403, Female-418] belonging to different populations of Uttar Pradesh, India were randomly selected with the age range of 16-45 years observed for phenylthiocarbamide to taste sensitivity. PTC tasting ability was measured by using a serial dilution method of Harris and Kalmus. The phenotypic frequency of tasters was higher as compared to non-tasters, and the same is statistically significant [x[2]= 11.92, df = 5, P = 0.036]. There were more females among tasters [67.94%] than males [64.76%]. This observation was statistically significant [x[2] = 14.79, df = 5, P= 0.011]. The frequency of PTC tasters is greater than non-tasters and the females have lower non-taster phenotypes as compared to males. This type of study will provide background information about genetic structure of population and serves as useful interaction of genetics, food preferences and dietary patterns
ABSTRACT
The ability to taste Phenylthiocarbamide [PTC], a bitter organic compound has been described as a bimodal autosomal trait in both genetic and anthropological studies. This study is based on the ability of a person to taste PTC. The present study reports the threshold distribution of PTC taste sensitivity among some Muslim populations of North India, as till now no detailed information is available. A survey was conducted among healthy individuals within the age range of 10-45 years who were randomly selected from among six populations viz; Syed, Sheikh, Pathan, Ansari, Qureshi and Saifi. The PTC tasting ability was measured using a serial dilution method of Harris and Kalmus. A bimodal distribution was observed from the graphs plotted for the PTC threshold distribution. The mean PTC threshold values [+/-SD] of the male and female individuals were calculated as 8.12 +/- 0.21 and 8.39 +/- 0.20, respectively. The threshold values among the six populations ranged from 7.71 to 8.81 among males, 7.44-9.04 among females and 7.86-8.91 as combined. The results found that females show a higher mean threshold value than males, though of no statistical significance. This type of study will provide brief information on the distribution of PTC sensory thresholds among some Muslim populations of North India. This study has some physiological relevance to highlight the adaptability of endogamous groups to behavioral traits in the same place.
ABSTRACT
Research on ABO group system has been of immense interest, due to its medical importance in different diseases. Till date only a few studies have been done on the prevalence and gene frequencies of A[1]A[2]BO and Rh[D] blood groups among the Muslim populations of Uttar Pradesh, North India. The data generated in the present work may be useful for health planners while making efforts to face the future health challenges in the region. This study was conducted to determine the prevalence and gene frequencies of A[1]A[2]BO and Rh[D] blood groups among six Muslim populations of Aligarh district, Uttar Pradesh, North India. Blood samples from a total of 724 healthy, unrelated individuals were drawn at random from the six different endogamous groups of Muslim populations of Uttar Pradesh, North India. A[1]A[2]BO and Rh blood grouping were carried out by standard slide agglutination method and allele frequencies were determined. In total 724 samples analyzed, the most frequent blood group was found to be group O 29.97%[n = 217], followed by A[1] 26.52%[n = 192], B 20.03% [n = 145], A[1]B 19.34% [n = 140], A[2] 2.90% [n = 21] and A[2]B 1.24% [n = 9]. The overall phenotypic frequencies of A[1]A[2] BO blood groups were O > A[1]>B > A[1]B > A[2]>A2B. The calculated allelic frequencies were 0.5619, 0.2214, 0.1973 and 0.0259 for group 1[degree], [1]b, Ial and I[a2], respectively. The Chi-square differences for A[1]BO blood groups among different Muslim populations were found to be significant [X[2] = 41.22, df = 25, p < 0.02]. Out of total 724 samples, 613 [84.67%] samples were Rh + ve and 111 [15.33%] were Rh-ve
Subject(s)
Humans , Male , Female , Prevalence , Rh-Hr Blood-Group System , IslamABSTRACT
Color blindness is a common X-linked genetic disorder. However, most of color blinds remain undetected due to absence of proper screening. Our study was to determine the prevalence of red-green color vision defects among Manipuri Muslim males and females. The study could help in decreasing birth of children with this disorder as Muslims commonly perform consanguineous marriage among themselves. Unrelated individuals of both sexes [Male-1352, Female-1302] belonging to six different populations were randomly selected and screened for red-green color vision defects using the Ishihara [pseudo-isochromatic plates] test from the area of Imphal East and Imphal west districts of Manipur, which is a small hilly state, situated in the north eastern extreme corner of India sharing an international boundary with Myanmar [Burma]. About 8.73% of males and 1.69% of females were found to be color blind. Among six different populations studied the males of Meitei population shows the highest frequency i.e. 14.93% while Naga population shows the least frequency of 3.75%. Among females, Meitei population again shows the highest frequency of 2.5% and least frequency is shown by Mughal and Naga populations 0.00% as not a single female color blind was found. Present study shows higher prevalence rate of color blindness as compared to other reported rates of India. Deuteranomaly cases occur in higher percentage than other types of color blindness. The higher prevalence rate observed in Muslims may be due to the hidden effect of consanguineous marriages