ABSTRACT
Stimuli-responsive nano drug delivery systems based on specific structures and physicochemical properties of tumor have been drawing wide attention from researchers, one of which is charge-reversal nano drug delivery system(CRN-DDS). CRN-DDS can effectively combine the merits of positive and negative charges in the drug delivery process in vivo, and it also has the good property of tumor-targeting. Although studies of CRN-DDS application in cancer therapy have already been reported, there is very little relevant Chinese literature, especially review articles. To fill in the blank, the foreign literatures about CRN-DDS were looked up in the last six years, classified CRN-DDSs by their different approaches of surface charge reversal, and summarized the studies on their applications in the cancer therapy. Last but not least, the prospect of CRN-DDS's development and application was preliminarily looked into in this article.