ABSTRACT
Objective To observe the relationship between serum gamma-glutamyltransferase (GGT) and the risk factors of metabolic syndrome (MS). Methods Between April and August 2010, a total of 4110 persons from the out-patient Department of Tianjin First CentralHospital, were divided into two groups, the less than and the older than 65-year-old groups. Items as body mass index (BMI), blood pressure, FPG, serum total cholesterol(TC) ,triglyceride(TG) ,alanine transaminase (ALT) , aspartate aminotransferase (AST) , GGT, serum high-density lipoprotein level (HDL-C) , serum low-density lipoprotein level (LDL-C) and uric acid(UA) were tested and data was analyzed by SPSS. All subjects were divided into normaland abnormal groups, according to the GGT level. Results 14.6 percent of thesubjects in the younger groups and 24.3 percent in the older groups were diagnosed as MS. Significant differences were noticed among MS groups and normal groups, regarding items as BMI, dystolic, ALT, GGT, HDL-C, FPG, and UA(F<0.05). There were significant differences between GGT normal group and abnormal group (F<0.05). The GGT levels were significant positively related to the levels of BMI, dystolic, TC, TG, FPG and UA with Rs as 0.212, 0.226, 0.362,0.200,0.120 and 0.213 (P<0.01), while negatively related to the HDL-C level (r=-0.23, P<0.001). Data from the regression analysis demonstrated thatdystolic, TG, FPG and UA were predictors for GGT (β =0.170, 0.293, 0.107, 0.094, P<0.05). Conclusion GGT levels were significantly related to the risk factors of metabolic syndrome.