ABSTRACT
<p><b>OBJECTIVE</b>To study the antiinflammatory effect of a compound TCM (Traditional Chinese Medicine) agent on animal models. The agent contains ant extractive and a blent of three herbal products, herba epimedii, fructus cnidii, and fructus lycii.</p><p><b>METHOD</b>Three animal models to induce experimental inflammation in rats, including carrageenin--induced paw edema, cotton-ball granuloma and adjuvant induced arthritis, were chosen to study the antiinflammatory effect of the TCM agent.</p><p><b>RESULT</b>The TCM agent showed a marked inhibitory effect on edema induced by all three types of inflammation in rats, the inhibitory rate of the TCM agent at the dose of 0.20, 0.40 and 0.80 g.kg-1 in granuloma model bing over 25% at 1 hour post oral administration, and being 23.8%, 22.7%, 39.7% at 6 hour. In addition, the TCM agent also showed a significant preventive as well as therapeutic effect on adjuvant induced arthritis in rats, and improved the pathological changes of the animal joints with the induced arthritis.</p><p><b>CONCLUSION</b>TCM agent has significant antiinflammatory effects on the three above mentioned animal models.</p>
Subject(s)
Animals , Male , Rats , Anti-Inflammatory Agents, Non-Steroidal , Therapeutic Uses , Ants , Arthritis , Drug Therapy , Capsules , Cnidium , Chemistry , Drug Combinations , Drugs, Chinese Herbal , Therapeutic Uses , Edema , Drug Therapy , Epimedium , Chemistry , Granuloma, Foreign-Body , Drug Therapy , Lycium , Chemistry , Materia Medica , Therapeutic Uses , Plants, Medicinal , Chemistry , Rats, WistarABSTRACT
Fuzheng Yiai Infusion is an effective remedy for micro - residual leukemia (MRL). It yields marked mitigation on the geneval condition of the patient and prevents complications by substantially improves the patients immunity, elevates the rate of total remission and living quality, prolongs the survival period. Studies on the indices including DNA index, rate of DNA non - uneuploid, ph' chromosome, and BCR/ ABL gene, showed that the recipe can inhibit or eliminate the actions of malignant clone. In vitro cultivation of cells proved that the recipe yields stimulating action on the proliferation of normal marrow cells, yet yields no stimulating action on leukemic cells. Animal experiments reveal this recipe markedly prolongs the survival period of MRL animal models.