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Arq. bras. cardiol ; 54(5): 319-322, maio 1990. tab
Article in Portuguese | LILACS | ID: lil-88012

ABSTRACT

Verificar a evoluçäo histológica do miocárdio em crianças portadoras de miocardite ativa submetidas ou näo à imunossupressäo, através de biópsias antes e depois de tratamento. Quatro grupos submetidos a diferentes esquemas de imunossupressäo e um grupo controle que recebeu somente drogas anticongestivas: grupo I - controle (4 pacientes), grupo II - prednisona (5 pacientes), grupo III - prednisona e azatioprina (9 pacientes), grupo IV - prednisona e ciclosporina (5 pacientes). Nenhum paciente do grupo I apresentou melhora histológica em período médio de 9 meses, enquanto que a melhora histológica ocorreu em 20% dos pacientes do grupo II, 67% do grupo III e 80% do grupo IV. Apenas pacientes do grupo III e IV apresentaram aspecto de miocardite em resoluçäo, após tratamento. A terapêutica imunossupressora com azatioprina ou ciclosporina, associada à prednisona, propiciou diminuiçäo da atividade da miocardite em maior proporçäo de casos do que o verificado nos tratados só com corticóide ou ainda sem imunossupressäo


PurposeTo analyse the histological evolution of endomyocardial biopsies from children with active myocarditis, submitted or not to immunosuppressive therapy. Patients and MethodsFour groups of patients were compared, clinically treated as follows: group Ianticongestive drugs (4 patients); group IIprednisone (5 patients); group III prednisone plus azathioprine (9 patients); group IVprednisone and cyclosporine (5 patients). ResultsNo patient from group I presented any histological improvement during a mean period of 9 months, while evident histological improvement occurred in 25% of patients from group I, 67% from group III and 80% from group IV. The microscopical aspect of resolving myocarditis was only observed in patients from groups III and IV, after treatment. Conclusion The immunosuppressive therapy with azathioprine or cyclosporine plus prednisone leads to decrease of active myocarditis intensity in a higher proportion of cases than the treatment with only prednisone or no immunosuppressive drugs.


Subject(s)
Humans , Male , Female , Infant , Child, Preschool , Child , Adolescent , Cardiomyopathy, Dilated/pathology , Immunosuppressive Agents/therapeutic use , Myocarditis/pathology , Myocardium/pathology , Immunosuppression Therapy , Azathioprine/therapeutic use , Prednisone/therapeutic use , Cardiomyopathy, Dilated/drug therapy , Follow-Up Studies , Cyclosporins/therapeutic use , Drug Therapy, Combination , Myocarditis/drug therapy
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