Effect of continuous nursing intervention on the ability of self-management and cancer pain of patients with non-small cell lung cancer during the interval of chemotherapy / 中国实用护理杂志

Objective:To explore and analyze the effect of continuous nursing intervention on the self-management ability and cancer pain of patients with non-small cell lung cancer during the interval of chemotherapy.Methods:Totally 86 patients with non-small cell lung cancer admitted to our hospital from March 2016 to December 2018 were selected as the study objects. According to the random number table method, they were divided into two groups. The control group received routine discharge guidance, and the observation group received continuous nursing intervention under multi-disciplinary cooperation. The self-management ability, cancer pain and quality of life of the two groups were compared before and after nursing.Results:Compared with before nursing, the scores of self-management ability of the two groups were improved, and the observation group was (128.88±8.88) points higher than (88.15±3.69) points in the control group ( t value was 27.775, P<0.01); compared with that before nursing, the Visual Analogue Scale (VAS) scores of the two groups after nursing decreased, the VAS scores of the observation group were (1.02±0.28) points, lower than that of the control group (3.15±0.15) points, the difference was statistically significant ( t value was 43.971, P<0.01); compared with that before nursing, the quality of life in the two groups improved after nursing, the scores in the observation group were (85.28±5.88), (88.02±6.88), (89.08±6.18), (90.02±2.57), (89.96±3.68) points, higher than (63.15±3.85), (65.05±4.28), (66.28±5.16), (67.15±3.25), (62.12±2.58) points in the control group, the difference was statistically significant ( t values were 9.637-12.632, P<0.01) . Conclusion:the continuous nursing intervention under multi-disciplinary cooperation can improve the self-management ability and quality of life of patients with non-small cell lung cancer during the chemotherapy interval, and reduce cancer pain.

Correlation of miRNA-181c expression in peripheral blood mononuclear cells with interferon-γ, chemokine (C-X-C motif) ligand 10, and Toll-like receptor 4 in children with autoimmune hepatitis / 临床肝胆病杂志

ObjectiveTo investigate the correlation of miR-181c expression in peripheral blood mononuclear cells (PBMCs) with interferon-γ (IFN-γ), chemokine (C-X-C motif) ligand 10 (CXCL10), and Toll-like receptor 4 (TLR4) in children with autoimmune hepatitis (AIH). MethodsA total of 27 children with AIH who were admitted to The Affiliated Hospital of Yanbian University from March 2015 to May 2019 were enrolled as AIH group, and 30 healthy children who underwent physical examination during the same period of were enrolled as control group. The expression of miR-181c in PBMCs and the expression of IFN-γ, CXCL10, and TLR4 were measured for the two groups. The t-test was used for comparison of normally distributed continuous data between two groups, and the Wilcoxon rank-sum test was used for comparison of non-normally distributed continuous data between two groups; the chi-square test was used for comparison of categorical data between two groups. The Pearson correlation coefficient was used to investigate the correlation of miR-181c expression with each index, and a logistic regression analysis was used to investigate the influence of each factor on AIH. ResultsCompared with the control group, the AIH group had significantly higher levels of the liver function parameters aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transpeptidase (GGT), and total bilirubin (TBil) (t=14.445,20.064，11.728,13.822, all P＜0.001). The AIH group also had significantly higher levels of IgA, IgM, and IgG than the control group (t=7.772, 5147, and 6771, all P＜0.05). The AIH group had significantly lower relative expression of miR-181c in PBMCs than the control group (0.784±0173 vs 1.106±0.224, t=5.819, P＜0.05). Compared with the control group, the AIH group had significantly higher levels of IFN-γ and CXCL10 and mRNA expression of TLR4 (t=6.949, 12.303, and 13.835, all P＜0.05). The correlation analysis showed that in the children with AIH, the expression of miR-181c in PBMCs was negatively correlated with IFN-γ, CXCL10, TLR4, AST, ALT, GGT, TBil, and IgG (r=-0.316, -0.348, -0.322, -0.427, -0.442, -0.408, -0.396, and -0.321, all P＜0.05). The univariate logistic regression analysis showed that AST, ALT, GGT, TBil, IFN-γ, CXCL10, TLR4 mRNA, and miR-181c were all included in the regression model (all P＜0.05) and were the influencing factors for the onset of AIH. ConclusionChildren with AIH have downregulated expression of miR-181c in PBMCs, which is closely associated with IFN-γ, CXCL10, and TLR4, suggesting that miR-181c may affect the development of AIH in children by regulating the immune system.