Deep venous thrombosis; mean platelet volume, D-Dimer and doppler sonography. patients of surgical wards of liaquat university hospital

Objectives: To study mean platelet volume [MPV] in deep venous thrombosis [DVT] as evaluated by D-Dimmer and Doppler sonography. Study Design: Case control study. Place and Duration: Department of Surgery, Liaquat University of Medical and Health Sciences Jamshoro/Hyderabad from May 2013 to April 2014

Subjects and Methods: A sample of 106 subjects; 50 controls and 53 diagnosed patients of DVT were studied. DVT patients were included according to inclusion and exclusion criteria and after results of Sonography and D-Dimer were available. The Blood samples were collected in bottles containing sodium citrate as anticoagulant. MPV was generated by Sysmex KX 21 hematology analyzer. Informed consent was sought from the volunteer subjects. The Data was analyzed using SPSS version 21.0. Statistically significance was defined at p-value of

Results: Mean platelet volume was elevated in deep venous thrombosis patients which were confirmed by clinical examination, sonography and D-Dimer. MPV was elevated in cases; 10.0 +/- 0.7fl compared to controls; 9.55 +/- 0.63fl [p=0.001]. D-Dimmer was elevated in deep venous thrombosis patients [p=0.0001]. Age, gender and platelet counts did not revealed any significant differences between cases and controls [p>0.0.05]

Conclusion: The present study reports elevated MPV in patients suffering from deep venous thrombosis and it is concluded that MPV may be considered as a risk factor for DVT

outcome of well's operation in the surgical management of rectal prolapse

To see the outcome of Well's operation in the surgical management of rectal prolapse. Quasi Experimental study. This study was carried out in Department of surgery, Liaquat University of Medical and Health Sciences, Jamshoro from 11-5-2006 to 10-05-2009. This study consisted of 30 cases of rectal prolapse admitted through the outpatient department, as well as from casualty department of Liaquat University Hospital Jamshoro. Detailed History was taken from all the patients with special regard to the rectal prolapse. Inclusion criteria were that all the adults patients [Male and female] of rectal prolapse on the basis of history and fit for anesthesia and surgery were included in the study. Exclusion criteria included unfit patients for general anesthesia, another local pathology like haemorrhoids or rectal tumor. Data was analyzed through SPSS software. Out of 30 cases, 14[46.7%] were males and 16[53.3%] were females. There was wide variation of age with mean age + SD was 40.67 + 12.4 years. Most of the patients had constipation 23[76.7%] cases, 20[66.6%] cases were presented with Mucus discharge, 11[36.6%] cases had urinary incontinence, 09[30.0%] cases had Diarrhoea and 07[23.3%] cases had bleeding. Co-morbidity factors were diabetes mellitus in 07[23.3%] cases, hypertension was present in 09[30.0%] and IHD was found only in 02[6.7%]. Ten [33.3%] cases were anemic, 05[16.66%] cases with HBsAg, 07[23.3%] had Hepatitis C and only 1[3.3%] case had duel viral infection. Complications were seen in all the cases, 28[93.3%] cases were found in majority who had pain after the procedure, 08[26.7%] cases developed the wound infection associated with retention of urine, 05[16.7%] had urinary incontinence associated with reactionary haemorrhage, 07[13.3%] had anal stenosis associated with incisional hernia, 01[3.3%] were found with ureteric damage, 03[10.0%] cases had sexual dysfunction and only 1[3.3%] case had Rectal stricture. Recurrence of rectal prolapse occurred in only 1[3.3%] patient. In conclusion, this study suggests that Wells operation may be a good choice for treatment of complete rectal prolapse, in view of its low complication and recurrence rates