ABSTRACT
AIM: To evaluate the effect of hyaluronate based gel (HAbg) in prevention of pleural thickening and adhesion in patients with tuberculous pleural effusions. METHODS: 52 patients with middle amount of tuberculous thoracic fluid accumulated, fluid bound, and pleura thickened more than 2 mm were divided into two groups at random. The patients of two groups were all given standard treatments with anti tuberculous drugs. HAbg was injected into intra thoracic cavity in treatment group (27 patients), while saline (NS) was introduced into intra thoracic cavity in control group (25 patients). Before and after HAbg injection, thoracic fluid routine and protein quantification were tested respectively. Pulmonary functions were measured after 2 weeks and 3 months of thoracic fluid absorption. RESULTS: Patients treated with HAbg showed significantly thinner pleura, lower proteins and white blood cell count in thoracic fluid, and higher FEV1% and FVC% for their pulmonary function in comparison with the control group. CONCLUSION: Intrathoracic injection of HAbg can prevent pleural thickening and improve the lung function in patients with excess fluid of tuberculous thoracic cavity.
ABSTRACT
AIM: To investigate the effects and safe of low molecular weight heparins (LMWH) in the treatment of patients with chronic pulmonary heart diseases (CPHD) at hypercoagulability state. METHODS: 65 patients were randomly assigned to treatment group (n=33) and control group (n=32). All patients were given routine treatments. The patients of treatment group were hypodermically injected with 4 100～6 150 U of LMWH per day for 7 days as a course. RESULTS: After 7 days of the treatments, the patients of treatment group showed better curative effect and significantly increase in PaO_2 and AT-III and decrease in PaCO_2 and FIB in comparison with the patients in control group (P