ABSTRACT
The objective of this study was to determine whether injection Midazolam could produce similar anesthesia, characterized by short duration of actions and clear headed and rapid recovery. Midazolam was compared with Thiopentone Sodium during day case short urological procedures. This was a prospective, single blinded, comparative, randomized, observational study. It was conducted in the Department of Anesthesiology and Surgical I.C.U, Civil Hospital Karachi and Dow Medical College, over a period of one year. Hundred randomly selected A.S.A I and A.S.A II patients receiving general anesthesia, were divided into two groups. 50 patients in each group, group I receiving injection Midazolam and the other, group II receiving injection Thiopentone Sodium, as IV induction agents, all patients received injection Pentazocine 0.3mg /kg and Injection Suxamethonium 1-1.5 mg/kg and anesthesia maintain with 02 + N2O+Halothane. At the end of surgical procedure all anesthetic agents were discontinued. Patients were extubated when they responded to verbal commands. Recovery from anesthesia was assessed by an evaluator who was unaware of the IV induction agents used for each patient. This study was based on two proforma I]. Intra operative proforma II] Recovery Room proforma. In group I [Midazolam group] after 5 and 10 minutes, no patient received 10 recovery points, after 20 minutes 6 patients received 10 recovery points and after 30 minutes 26 patients received 10 recovery points and those who didn't score 10 points after 30 minutes were 18 patients. In group II [Thiopentone Sodium group] after 5 minutes 1 patient, after 10 minutes 2 patients, after 20 minutes 22 patients, after 30 minutes 23 patients received 10 recovery points, patients who didn't score 10 points after 30 minutes were just 2. After induction with injection Thiopentone Sodium recovery is more rapid as compared to the induction with injection Midazolam, so injection Thiopentone Sodium is the better of the two drugs under comparison for day case urological procedures