Experimental murine toxocara canis histopathological study of chronic renal infection, transplacental transmission and ultrastructural study of egg shell

Histopathological examination of kidney of Swiss albino mice, 21/2 months after infection with Toxocara canis eggs revealed various pictures of pathological affection. There was diffuse mesangioproliferative glomerulonephritis with mesangial expansion of most of glomeruli. Some glomeruli showed severe hyalinosis with marked adhesions to the bowman's capsule. The lumina of glomerular capillaries were markedly obliterated. There was also cystic dilation of tubules with proteinaceous casts. The interstitial tissue showed mild inflammatory edema. Chronic inflammatory cellular infiltration to form granulomatous inflammation was noticed. Transplacental transmission of Toxocara larvae was assessed in embryo of pregnant female Swiss albino mice which were infected with Toxocara eggs in the 1st week of pregnancy. The larvae were detected in the liver of embryo. Ultrastructural study of the egg shell revealed its formation of four layers, a thin uterine membrane with occasional small bulges, vitelline layer, thick homogenous layer, and fibrous lamellar and lipid layer

Effect of repeated doses of praziquantel on the liver of premature albino mice

Bilharziasis constitutes a national health problem in Egypt. Millions of individuals were infested with bilharziasis. They form continuous source of infection and spread of the disease allover the country. Praziquantel, the antischistosomal drug was given successfully in a single oral dose. Some workers divided the single dose twice or trice. Others repeated the dose using different regimens with encouraging results. In the present work, therapeutic dose of praziquantel was administered for 5 days to postnatal Swiss albino mice aiming to detect the teratogenic, toxic or pathologic effects on their livers. It was observed that praziquantel induced variable degenerative changes in the liver in the form of focal areas of cell necrosis, fatty degeneration with mild inflammatory cell infiltration in the first and the second days after stop of the drug. These degenerative changes were massive 7 days later

Parasitic [helminthic] infection among Babil school children at Menofia governorate

This study was carried out at Babil Primary Schools. The target sample was composed of 800 males and 600 females. Their ages ranged from 6-12 years. The results showed that 25.5% of total sample were suffering from parasitism. The most prevalent parasites were Schistosoma hematobium [10.1%], followed by Ascaris lumbricoides [6.9%]. Schistosoma mansoni [4.5%] Enterobius vermicularis [3.3%], the last parasite detected was Hymenolepis nana [2.4%]. It was observed that there is a significant difference between infection rate among high and low social classes also between infected and non infected groups regarding to personal habits and environmental conditions. Evaluation of the nutritional status of the children cleared that there is observable growth retardation among the infected group. Socio-economic development, environmental sanitation, health education, active participation of school authorities for early diagnosis and treatment of parasitism are highly recommended