ABSTRACT
OBJECTIVES@#To compare the differences in clinical characteristics between Type 1 diabetes mellitus (T1DM) and fulminant Type 1 diabetes mellitus (FT1DM), and to reduce the missed diagnosis, misdiagnosis, and mistreatment of FT1DM by medical staff.@*METHODS@#A total of 101 hospitalized patients with T1DM (including 8 cases of FT1DM) were enrolled in this study from Changsha Central Hospital between June 2012 and December 2018. Clinical characteristics of the 8 FT1DM patients were collected and compared with all T1DM patients.@*RESULTS@#All FT1DM patients were adult with the average age of (30.25±5.28) years old, accompanied by severe diabetic ketoacidosis (DKA) occurred within 1 week after onset. Moreover, pancreatic beta cells in these patients were destroyed and the islet-related antibodies were negative, while the serum pancreatic enzyme levels were increased. Compared with classic T1DM patients, the plasma glucose levels in FT1DM patients were much higher [(41.89±12.54) mmol/L vs (22.57±9.74) mmol/L], but glycosylated hemoglobin (HbA1c) and fasting C peptide levels were significantly lower [(6.08±0.41)% vs (10.87±2.46%)%, @*CONCLUSIONS@#The onset time of FT1DM patients is very urgent via driving DKA. These patients have higher blood glucose concentration than classic T1DM patients, accompanied by electrolyte disturbances, impaired renal function, partially impaired liver function, as well as gastrointestinal symptoms and elevated trypsin. Most FTDM patients are adolescents and adults with no gender difference, especially pregnant women who are at high risk. Lifelong insulin dependence in FT1DM patients should be paid more attention in clinical treatment.
Subject(s)
Adolescent , Adult , Female , Humans , Pregnancy , Young Adult , Diabetes Mellitus, Type 1/complications , Diabetic Ketoacidosis , Glycated Hemoglobin/analysis , Insulin , Sex FactorsABSTRACT
@#Objective To explore the rehabilitation effect of group education intervention in self-control on schizophrenic patients. Methods 112 schizophrenic patients were divided into study group (56 cases) and control group (56 cases). Two groups were treated with antipsychotics. The control group was subjected to general healthy education, while the study group received education intervention of self-control. All patients of two groups were assessed by Self-care Behavior Questionnaire(SCBQ), Brief Psychiatric Rating Scale(BPRS) and Social Disability Screening Schedule(SDSS) before and affter intervention, and drug-compliance was also assessed.Results After one year, the total score of SCBQ was significantly higher in the study group than in the control group, while the total scores of BPRS and SDSS were significantly lower in the study group than in the control group (P<0.01); Drug-compliance was significantly more in the study group than in the control group(P<0.01).Conclusion Group education intervention of self-control can improve distinctly the ability of self-control disease, have positive effect on remission psychical symptom, and improve the social function and retention psychosomatic healthy.
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of ferment powder caterpillar fungus on cytochrome P450 isozymes CYP1A2, CYP3A4 and CYP2E1.</p><p><b>METHOD</b>The methods of Cocktail probe drugs were used. The rats were randomly divided into two groups. One group were given ferment powder caterpillar fungus once daily orally for ten days. Another group received orally normal saline one daily as the blank control. After ten days of treatment, the rats were given probe drugs of coffine, dapsone and chlorzoxazone and the blood was taken out by femoral catheterization. The plasma concentration of probe drugs were determined by HPLC. Data of plasma drug level-time were disposed with DAS Ver 2.0.</p><p><b>RESULT</b>The metabolism of caffeine and dapsone speeded up after receiving ferment powder caterpillar fungus, but the metabolism of chlorzoxazone was hardly changed.</p><p><b>CONCLUSION</b>It suggested that ferment powder caterpillar fungus tended to be the inducer of CYP1A2 and CYP3A4. But the CYP2E1 was hardly affected.</p>
Subject(s)
Animals , Male , Rats , Caffeine , Metabolism , Chlorzoxazone , Metabolism , Cytochrome P-450 Enzyme Inhibitors , Cytochrome P-450 Enzyme System , Metabolism , Dapsone , Metabolism , Drugs, Chinese Herbal , Fermentation , Random Allocation , Rats, WistarABSTRACT
Objective To study the effect of a polysaccharide from cuscuta chinensis lam (PCCL) on antisenility and its mechanism. Methods Sixty Kunming mice were randomized into 6 groups. The three PCCL groups were administrated with PCCL of 100, 200, 400 mg?kg -1?d -1 orally, the positive control group with vitamin E of 200 mg?kg -1?d -1, the model group and control group with the same volume of control solution only. At the same time, the model group, the positive group and the three PCCL groups were subcutaneously injected of 5% D-gal at the dose of 0.5 ml at the nape, and the control with the same volume of saline solution. Seven weeks later, the MDA, SOD activity, GSH-PX activity in the liver and kidney of mice and lipofuscin (LF) in mouse brain were detected with the methods of TBA, Nitrate, DTNB and Sohal, respectively. The data were analyzed with SPSS software and the data between groups were analyzed with one-factor variance analysis. Results Thymus index and spleen index dropped, LF rose in brain, malondialdehyde (MDA) content rose and the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) dropped in liver and kidney in senile mouse model. PCCL administration of 100, 200, 400 mg?kg -1?d -1 made thymus index and spleen index rising, LF dropping in brain, MDA content dropping,SOD and GSH-PX LF rising in liver and kidney of senile mouse model. Conclusion PCCL may postpone senility, which mechanism probably connected with rising immunity, eliminating oxygen free radicals and antilipoperoxidation.
ABSTRACT
AIM: To analyze the chemical constituents of essential oil in Ephedra Sinica Stapf from Gansu Province. METHODS: The essential oil in Ephedra Sinica Stapf was extracted by steam distillation and analyzed by gas chromatography-mass spectrometry(GC-MS). RESULTS: 71 Compounds were identified from Ephedra Sinica Stapf of 3 different sources(Minqin,Zhenyuan and Gulang County),and contained 28 same components such as tetramethylpyrazine、linalool、?-terpineol、4-terpineol、d-?-terpineol、hexadecanoic acid and so on.The contents of d-?terpineol and hexadecanoic acid in Ephedra Sinica Stapf were the highest. CONCLUSION: Essential oils in Ephedra Sinica Stapf from Gansu Province do not contain 1-?-terpineol.
ABSTRACT
OBJECTIVE: To study the antitussive, antiasthmtic, anti-inflammatory and diuretic effects of Herba Ephedrae cultivated artificially in Gansu province and to compare which with the wild Herba Ephedrae. METHODS: Each pharmacological action index was determined by concentrated ammonia method, windpipe capacity method, pinna swelling method and metabolic cage method. RESULTS: Both of the two kinds of Herba Ephedrae could reduce the cough responses of mice, resist the spasmodic contraction of the tracheal smooth muscles, reduce the swelling of auricle of mice and increase urine volume of rats. CONCLUSIONS: Herba Ephedrae cultivated artificially in Gansu province are equivalent to the wild one in terms of the antitussive, antiasthmtic, anti-inflammatory and diuretic effects thus it can serve as a substitute for the wild one.
ABSTRACT
Objective To study the activities of the alcoholic extract from Fructus Polygoni Orientalis (EFPO) against antioxidation. Methods The peroxidation in homogenate of rat heart, liver and kidney was induced by ?OH generation system Fe2++ascorbic acid. Malondialdehyde (MDA) was determined by TBA colorimetric method. Superoxide (O-2) from zymosan-stimulated neutrophils of rat was measured by NBT reduction method. H2O2-caused hemolysis of erythrocytes was measured by spectrometry. Results MDA in homogenate of heart, liver and kidney of rat that induced by ?OH generation system Fe2++ascorbic acid was inhibited by 6.3, 12.5, 25, 50, 100, 200 ?g/L EFPO; IC50 of EFPO to MDA in heart, liver and kidney was 31.8, 32.5 and 40.2 ?g/L respectively and its dose-effect relation was of negative relativity and the relative coefficient was -0.886, -0.874 and -0.918 (all P