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Objective:To explore the effect of intraoperative autologous blood transfusion on coagulation function and inflammatory reaction after cesarean section.Methods:By retrospective analysis, 114 parturients who underwent caesarean section in our hospital from March 2017 to February 2019 with intraoperative blood transfusion were selected and divided into autologous group (57 cases) and allogeneic group (57 cases) according to the source of intraoperative blood transfusion. The changes of coagulation markers and inflammatory reaction indexes were detected and recorded respectively before and 3 days after operation, respectively. And the complications after blood transfusion were compared between the two groups.Results:On the 3rd day after operation, the expression of P65 gene and the optical density of P65 in both groups increased significantly, but the autogenous group was lower than the allogeneic group ( P<0.01); the granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-6 and IL-1β in both groups increased significantly, but the autogenous group was lower than the allogeneic group ( P<0.01); the D-dimer (D-D), thrombomodulin (TM), tissue plasminogen activator (t-PA) and fibrinolytic-antifibrinolytic complex (PAP) in both groups were slightly higher than those before operation, and the data between the two groups also changed, but with no statistical significance ( P>0.05). In addition, the incidence of complications in the autogenous group was 5.26%(3/57), which was significantly lower than that in the allogeneic group (17.54%, 10/57) (χ 2=4.25, P=0.04). Conclusions:Autologous blood transfusion has no significant effect on the coagulation function of parturients during cesarean section, but compared with allogeneic blood transfusion, autologous blood transfusion can effectively reduce the inflammatory reaction of parturients after operation, and has a significant effect on reducing the occurrence of complications after operation, which is conducive to improving the prognosis.
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Objective To observe the analgesic effect of quadratus lumborum block (QLB) in cesarean section under general anesthesia.Methods 50 patients underwent cesarean section under general anesthesia were randomly divided into two groups (n =25):patients in QLB group (group Q) received QLB at the end of surgery with 0.3％ ropivacaine 25ml,and the control group (group C) patients were disinfected at the same site but did not puncture.The visual analogue scale (VAS) and pain Bruggrmann comfort score (BCS) were recorded at 2,6,12,24,and 48 hours after surgery.The patient's general condition,vital signs and postoperative analgesia-related adverse reactions were recorded.Results There were no significant differences between the two groups in general information and surgical related indexes (P ＞ 0.05).The VAS scores of the Q group were lower than the control group at 2,6,12 and 24 hours,and the BCS score was higher than that in the control group (P ＜ 0.05).There was no difference in VAS score,BCS score after 48 hours,and no difference in adverse reaction rate between the two groups (P ＞ 0.05).Conclusions Quadratus lumborum block combined with intravenous analgesia can reduce the pain score within 24 hours after cesarean section under general anesthesia and improve postoperative analgesia comfort.
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On the basis of studying processing method and quality control standard of Realgar,we did researches on the differences of toxicity and efficacy between new processing method(Washed by Acid)and traditional processing method(Grinding Without Water).The result showed that the efficacy was improved and the toxicity reaction Was lowered after Realgar being processed by new method.