ABSTRACT
The formalin test is widely believed to provide a more valid model for clinical pain than tests with phasic mechanical or thermal stimuli. However; the different implementations of the test in use pose the possibility of confounding results. This study evaluated the effects of different injection sites on the pattern of nociceptive responses. The responses to forepaw injection was found to be significantly higher than that of hind paw injection in the first phase while the response to plantar injection was found to be significantly higher than that of dorsal injection. We conclude that the choice of injection site has some effects on the pattern of nociceptive responses
Subject(s)
Injections , Pain MeasurementABSTRACT
The study investigated whether the relationship between sex and experimental pain report was explained by blood pressure at rest; or during pain task; or both in healthy; young adult females. Univariate analyses indicated significant positive correlation between baseline systolic blood pressure; systolic blood pressure reactivity; and heart rate reactivity ; but not baseline diastolic blood pressure; diastolic blood pressure reactivity; heart rate; weight; height and pain sensitivity. However none of the positively correlated parameters could significantly predict pain threshold or pain tolerance
Subject(s)
Adult , Blood , Bread , Female , Heart , Pressure , SpleenABSTRACT
Against a backdrop of neurological effects; the effects of acute and chronic administration of vitamin C (600mg/kg) on pain processing were investigated in male rats. Chronic administration of vitamin C induced significant thermal hyperalgesia while acute administration had no effect. In addition; the intraperitoneal administration of vitamin C produced observable abdominal writtings similar to what has been observed with acetic acid. We conclude that chronic vitamin C exerts facilitatory central nervous system effects and a possibility of using intraperitoneal injection of vitamin C as an animal model of pain is suggested