ABSTRACT
Objective To analyze the acoustic features of plosive consonants in Uyghur as spoken by persons with post-palatoplasty velopharyngeal insufficiency.Methods Thirty-one Uyghur-speaking children without a speech disorder were selected as a control group,while 28 others with velopharyngeal insufficiency (VPI) formed the VPI group.All were recorded speaking 9 Uyghur words which contain the plosive consonants/b/,/d/and/g/.The consonants' duration (CD),amplitude (CA),their first formants (VF1),second formants (VF2),third formants (VF3) and fourth formants (VF4) as voiced as well as the voice onset time (VOT) were measured and analyzed using the PRAAT software for the two groups.Results The VF1,VF3 and VF4 of the plosive consonant /b/ were significantly lower for those in the VPI group than among the controls,and the CD of/b/was significantlylonger.There were also significant differences between the two groups in terms of the VF1s,VF3s and CDs of the other plosive consonants.The VOTs of the consonant/b/,/d/ and/g/ were (0.12±0.05)s,(0.10±0.03)s and (0.09±0.03) s,respectively,with an occurrence rate of up to 100％ in the control group,significantly different from those in the VPI group (P＜0.05).Conclusion The acoustic features of the three plosive consonants/b/,/d/ and /g/ can distinguish Uyghur-speaking children with velopharyngeal insufficiency from those with normal speech.
ABSTRACT
Objective To establish an animal experimental model of immediately peri-implant bone defects in rabbit mandibular anterior teeth,and to investigate the osteogenetic capability of dental pulp stem cells (DPSCs) on bone defects around implant.Methods Eight rabbits were involved,whose bilateral mandibular anterior teeth were removed to form the bone defects with 2 mm × 3 mm area on the buccal side of tooth extraction sockets,and then the implants were implanted immediately.The rabbits were divided into two groups.The implants were Bio-oss with DPSCs and Bio-oss with phosphate buffer saline respectively for the experimental group and the control group.The bone regeneration in the defect region was evaluated by general observation,hematoxylin-eosin (HE) staining and Goldner trichrome staining and scanning electron microscope (SEM) at 4 weeks after implantation.Results The implantations were successfully conducted,and the implants were stable.There was no significant difference between the implants.The results of the HE staining and the trichrome staining showed that in the experimental group,new bone tissue and partial woven bone formed,and the properties of the newly formed bone cells were large,abundant,well differentiation,and arranging in woven pattern.While in the control group,the new bone-like tissue formation was less,and the mature cell differentiation was ordinary.The SEM results showed that there was a higher osteointegration between the new bone and the implant in the experimental group comparing with the control group.Conclusions The capability of Bio-oss with DPSCs is relatively superior to single Bio-oss in osteogenesis and osseointegration.