ABSTRACT
The major obstacle limiting the use of aminoglycoside, antibiotics has been and continue to be the possibility of drug induced ototoxicity and nephrotoxicity. Changes in biochemical parameters related to nephropathy before and after of nigella sativa is observed. Five Rabbits were included in the study. Nephrotoxicity was induced with gentatamycin. Extract of Nigella Sativa was given for 20 days and estimated the biochemical changes related to kidney function. Blood samples were taken before and after the administration of Nigella Sativa [at 11 days and 21 days]. It is therefore concluded that although nigella sativa shows a significant effect on nephrotoxicity induced by gentamicin but its effect on the level of serum calcium and cholesterol may be dangerous. However further research is needed on large number of rabbits to reach on a definite