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Abstract@#<i>Nitraria Sibirica</i> Pall (NSP) is an annual plant of the family <i>Zygophyllaceae</i> that has been used for many diseases. The fruits of NSP have been used as a folk medicine for thousands of years in Mongolia and China. Numerous bioactive phytochemicals, such as flavonoids, alkaloids and glycosides, have been isolated and identified from NSP that are responsible alone or in combination for various pharmacological activities. However, to date, anti-nephrotoxicity effects of NSP on Gentamcin-induced animal models have not been investigated.@*Method@#In the experimental design, 24 Wistar rats were randomly isolated into three groups such as control, gentamicin and NSP. The renal injury was modeled by intramuscular injection of Gentamicin for 5 consecutive days (150 mg/kg). The doses of 25 mg/kg of aqueous extract of NSP were administrated by oral gavages for 14 consecutive days in rats. At 14 days for the rest of them, serum samples were collected for renal function biochemical tests (Blood urea nitrogen, creatinine, creatinine clearance and glomerular filtration rate).@*Result@#We demonstrated that treatment of NSP aqueous extract significantly reduced blood urea nitrogen (BUN), serum creatinine (Cr) levels and increased creatinine clearance, glomerular filtration rate (GFR) levels in Gentamicin-administrated rats.@*Conclusion@#These data suggested that NSP shown good effect for anti-inflammatory of kidney.
ABSTRACT
Introduction@#Tribulus terrestris L. (TTL) is an annual plant of the family Zygophyllaceae that has been used for many diseases including urinary tract diseases. The fruits and roots of TTL have been used as a folk medicine for thousands of years in Mongolia, China, Iraq, India, Sudan and Pakistan. Numerous bioactive phytochemicals, such as saponins, flavonoids, alkaloids and glycosides, have been isolated and identified from TTL that are responsible alone or in combination for various pharmacological activities. However, to date, the nephroprotective effects of TTL on cisplatin-induced animal models have not been investigated.@*Purpose@#The present work aimed to investigate the protective effects of different doses of Tribulus terrestris L. (TTL) against cisplatin-induced nephrotoxicity in mice.@*Materials and methods@#The renal injury was modeled by intraperitoneal injection of cisplatin for 5 consecutive days (5 mg/kg). Nephroprotection of TTL was investigated by oral administration of different doses of TTL aqueous extract at a daily dose of 20 mg/kg and 40 mg/kg for 14 consecutive days, starting 7 days prior to cisplatin administration.@*Results@#We demonstrated that pretreatment with different doses of TTL aqueous extract significantly reduced blood urea nitrogen (BUN) and serum creatinine (Cr) levels and histophatological changes observed in cisplatin-administrated mice.@*Conclusion@#These data suggested that TTL might be a potential candidate for neoadjuvant chemotherapy of cisplatin. The dose of TTL 40 mg/kg was the most effective.
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Background: Today over 1 million people have hypertension in the world. 1.5 billion people have symptoms of the diseases living difficulty. The hyperpiesis is 64% brain hemorrhage causes, and 49% of heart attack diseases. Blood pressure or hyperpiesis is the leading cause of adult diseases in Mongolia. With hypertension diagnoses, 19811 people hospitalized in patient treatment and 46022 people have received outpatient care through Mongolia. The most present of Mongolians regularly use medicines for reducing arterial pressure. In this research, we chosen the Enap medicine that is used common; 5 mg, 10 mg and 20 mg Enap are used at imported and domestic industry in the pharmaceutical market, Mongolia. Aim: To research some indicators of Enap pharmaceutical market which is used common in the treatment by Mongolians. Method: Based on the statistics from Mongolian Customs, when we research about the Enap market, we used the drug economic analysis methods including comparative research methods and content analysis research methods, respectively. Results: Our result shows that the 66.7% of all Enap in Mongolian pharmaceutical market is imported, and other 33.3% medicine is produced in domestic manufacturers, Mongolia. In Mongolia, 8 companies imports the Enap medicines from the biggest farms like KRKA, Denk Pharma, Berlin Chemie and Akrihin-akri. In the comparison research for Enap sales, there are 8 importer companies, the Х1 company sells the most, and it’s 22.4 times much than the lowest sales. In the research for Enap /10mg/average prices, the imported products cost 324 MNT but the domestic products cost 1525 MNT.
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Introduction: Ribes diacanthum Pall. (Saxifragaceae), a Mongolian folk medicinal plant, aqueous extract of its aerial parts (leaves, stems, fruits) has been used to treat urinary system diseases. It has been reported that the aqueous extract of RDP can control kidney stones and stimulate the diuretic effect. Some chemical studies showed that ethyl acetate extract of RDP exhibits significant ability of scavenging free radicals. However, to date, the nephroprotective effects of RDP on animal models have not been investigated. Purpose: The present work aimed to investigate the protective effects of different doses of Ribes diacanthum Pall (RDP) against cisplatin-induced nephrotoxicity in mice. Materials and methods: The renal injury was modeled by intraperitoneal injection of cisplatin for 5 consecutive days (5 mg/kg). Nephroprotection of RDP was investigated by oral administration of different doses of RDP aqueous extract at a daily dose of 10 mg/kg, 20 mg/kg and 40 mg/kg for 14 consecutive days, starting 7 days prior to cisplatin administration. Results: We demonstrated that pretreatment with different doses of RDP aqueous extract significantly reduced blood urea nitrogen (BUN) and serum creatinine (Cr) levels and histophatological changes observed in cisplatin-administrated mice. Conclusion: These data suggested that RDP might be a potential candidate for neoadjuvant chemotherapy of cisplatin. The dose of RDP 40 mg/kg was the most effective.