The present situations and problems on description of the constitution in pharmaceutical interview sheets and side effect literature / 医薬品情報学

<b>Objective </b>: There are two types of studies on the relationship between adverse events and genetic background and the relationship between constitution and genetic background.  To investigate the relationship between adverse events and constitution retrospectively, we first reviewed the appearance of the constitution responsible for the adverse events in the relevant sources of information.<br><b>Methods </b>: Fifty two pharmaceutical interview sheets, 150 case reports and two manuals; “jyudaina fukusayou kaihi notameno fukuyaku sidou jyouhousyu”, “jyutoku fukusayou sikanbetu manual” were selected for review.<br><b>Results </b>: Fourteen items about the constitution were found in the pharmaceutical interview sheets.  No items about the constitution were found in the case reports and manuals.<br><b>Conclusion </b>: Rules for the preparation of pharmaceutical interview sheets and case reports to use the constitution information is necessary for retrospective analysis of this issue.

Development of Information Code in which Pharmacologic Action is Expressible and Construction of Structure Similarity Search System / 医薬品情報学

  In order to facilitate the simultaneous search of structural and pharmacological information for drugs, we studied the design of the coding system for pharmacological information.  In this study, pharmacological information was defined as information that describes the nature of principal action, specifically “where and how the drug acts”.  Furthermore, we developed a standardized code generation system for describing such information.  First, in order to describe the drug delivery location, organs and subcellular organelles were assigned hierarchical codes by referring to the hierarchical classification of human anatomy.  Next, drug interacting receptors and their action results were encoded and coupled to the location codes, and procedures for generating pharmacological information codes were developed.  Regarding drug structure information, Cartesian coordinates that describe the planer structure were transformed into sequences of numbers in order to obtain molecular fingerprints, which were then used to generate drug structural information codes.  Drug information was compiled into a database that comprises the two categories of codes (pharmacological/structural codes), and a simultaneous search system was developed that links structural similarity and pharmacological information.  A web-based interface for searching the structural information codes was created, and searches could be performed as expected.