ABSTRACT
This study was designed to synthesize chemically 2-aminothiadiazole derivatives and conversion to Schiffs base. The principle synthesis of these compounds was to involve three steps: First: by thermal cyclization of thiosemicarbazied with carbon disulfide in the presence of potassium hydroxide dissolved in anhydrous ethanol to yield 2-amino-5- mercapto-l,3.4-thiadiazole. Second: by thermal cyclization ofthiosemicarbazied with substituted carboxylic acid and sulphuric acid, to yield 2-amino-5-R-I,3,4-thiadiazole. Third: Schiff 's base formation by reflux of aromatic aldehyde with 2-amino-5-R-l, 3, 4-thiadiazole in the presence of ethanol. The chemical structures of all prepared compounds were confirmed by spectral data [UV-visible and 1 R spectroscopy] tables [1, 2, and 3]