ABSTRACT
Our Objective was to Evaluate the D-dimer level among adult patients in Al-Quwayyah Government Hospital, Saudi Arabia. A prospective study was conducted during four months period in 2012. The inclusion criteria were patients eighteen years of age and above who have surgical procedure. Information was obtained by the Laboratory Department of Al-Quwayyah Government Hospital. A Total of 46 patients were done a D-dimer test in a hospital. The patient's constituted 32 males and 14 females and the average age was 60 years. D-dimer test, findings indicated that 69.5% was found abnormal level of D-dimer (elevated) and 30.5% was normal D-dimer level. The average age of abnormal D-dimer group is 59 years old (Male and female). No difference in the result of abnormality of D-dimer. Levels were found between male and female, but there were found a significantly relationship that associated with increasing of the age of patients. In this study, the proportion of the high level of D-dimer in this group was 69.5%. The increase in the client age plays a vital role in the increase of D-dimer level. Advices and recommendations are should be pay attention to help those patients suffering of elevated D-dimer level.
ABSTRACT
The aim of the study was to formulate intrapocket dental films, which could be easily placed into the periodontal pocket, and be capable of delivering therapeutic concentrations of ofloxacin for prolonged period of time at a much lower dose, hence obviating untoward side effects. Intrapocket device containing ofloxacin was prepared using 255.20 mg of ofloxacin, 2.0% plasticizer diethyl phthalate and 1.4g ethyl cellulose. The device was optimized on the basis of evaluation parameters such as weight variation, content uniformity, surface pH, in vitro and in vivo release studies. Films showed sustained in vitro release for a period of 11 days. In vivo release studies showed that drug concentrations were maintained above MIC value for entire period of release studies. The samples from this study were capable of inhibiting the growth of most test strains. Ofloxacin in carrier polymer ethyl cellulose showed extended spectrum of antimicrobial activity. Stability studies were conducted on optimized formulation and degradation rate constant was found to be 1.2056 10-4/day. The drug released locally and had high benefit to low risk ratio as compared to systemic administration, which is unacceptable due to, low benefit to high-risk ratio. Hence low dose site-specific films is a better alternative.
ABSTRACT
Psoriasis is a chronic T lymphocyte mediated autoimmune inflammatory disorder that affects the skin, joints, and tendons. Betamethasone dipropionate (BD) has anti-inflammatory, immunosuppressive,and antiproliferative activity. The aim of this study was to investigate and evaluate a nanoemulsion topical gel of betamethasone dipropionate. For the preparation of nanoemulsion eucalyptus oil and babchi oil was taken. Nanomulsions were prepared by aqueous phase-titration method. Pseudoternary phase diagrams were constructed for the identification of nanoemulsion existence zones. Prepared nanoemulsions were subjected to different thermodynamic stability tests and characterized for droplet size, viscosity and refractive index. In vitro skin permeation of betamethasone dipropionate through rat abdominal skin was determined by the Franz diffusion cell. The prepared nanoemulsion gel is a potential vehicle for improved topical delivery of BD for better treatment of psoriasis.
ABSTRACT
Tablets containing zidovudine and lamivudine (ZILA) were prepared by direct compression method. Optimization studies were done for the selection of glidant, lubricant and coating materials. Evaluation of granuleswere done on the basis of preformulation studies. The prepared tablets were evaluated for physicochemical properties. The in- vitro release studies were performed as per USP and compared with marketed product. The release of zidovudine and lamivudine were analysed by high performance liquid chromatography (HPLC). The ZILA tablets exhibited better release characteristics than the marketed product. Stabilities studies were performed in both blister as well as cold form blister packings. Stabilities studies revealed the suitability of blister package in comparison to the cold form blister packing. From the study it was concluded that the selected composition can be used for the preparation of tablets that can be used for the treatment of HIV-1 and Hepatitis-B after performing studies on animals for its suitability and efficacy.