ABSTRACT
Single-photon emission computed tomography (SPECT) can be used as a non-invasive tool for the assessment of coronary perfusion. Aim: To assess ventricular perfusion and function by SPECT in patients with single vessel coronary artery disease. Material and Methods: Among patients with indications for a coronary artery angiography, those with significant lesions in one vessel, were selected for the study. Within 24 hours, cardiac SPECT examinations on basal conditions and after high doses of dipyridamole, were performed. SPECT data from 38 patients with a low probability of coronary artery disease was used for comparisons. Results: Ten patients aged 61 ± 8 years (seven men) were studied. Visual analysis of SPECT revealed signs suggestive of ischemia in eight patients. The remaining two patients did not have perfusion disturbances. SPECT detected eight of ten abnormal vessels reported in the coronary artery angiography. There were two false negative results Summed stress, summed rest and summed difference scores were 9.78 ± 6.51, 3.22 ± 5.07 and 6.33 ± 4.97, respectively. The ejection fractions under stress and at rest were 53 ± 11.7% and 61 ± 15.7% respectively (p < 0.01). The figures for the control group were 69.1 ± 13.5% and 75.2 ± 12.04% respectively (significantly different from patients). Two patients had a summed motion score above 14.9. Likewise, two patients had a summed thickening score above 10.9. Conclusions: SPECT detected 80% of coronary lesions found during coronary artery angiography. Visual analysis of perfusion is highly reliable for diagnosis. Quantitative parameters must be considered only as reference parameters.
Subject(s)
Aged , Female , Humans , Male , Middle Aged , Coronary Artery Disease/physiopathology , Ventricular Dysfunction, Left/physiopathology , Coronary Angiography , Coronary Artery Disease , Observer Variation , Perfusion Imaging , Prospective Studies , Severity of Illness Index , Tomography, Emission-Computed, Single-Photon , Ventricular Dysfunction, LeftABSTRACT
Se revisa el tema de fibrodisplasia osificante progresiva (FOP), que es una enfermedad autosómica dominante infrecuente a propósito de un caso pediátrico. El cuadro debuta como aumento de volumen transitorio y fluctuante en extremidades superiores y es estudiado con diversas imágenes radiológicas e isotópicas. Se discute la patogenia, presentación clínica y terapia así como la utilidad relativa de las diferentes técnicas diagnósticas en la caracterización de la enfermedad.
Subject(s)
Humans , Female , Child , Myositis Ossificans/diagnosis , Myositis Ossificans/therapy , Tomography, X-Ray Computed , Adrenal Cortex Hormones/therapeutic use , Edema/etiology , Bone and Bones , Radiography, Thoracic , Recurrence , Treatment OutcomeABSTRACT
Los estudios isotópicos cardíacos en niños tienen distinto enfoque que en adultos, en quienes la pesquisa y el seguimiento de la enfermedad coronaria (EC) juegan un papel importante y bien reconocido. En general, las causales de solicitud corresponden principalmente a patología de tipo congénito o inflamatorio. La enfermedad de Kawasaki (EK) (vasculitis) que produce alteraciones coronarias severas puede ser fácilmente evaluada no invasivamente con los marcadores de perfusión. En esta presentación se discuten las principales causas de requerimiento de estudios de perfusión y viabilidad miocárdica en pediatría y se presenta la experiencia en este campo del Hospital Clínico de la Universidad de Chile, con 18 exámenes SPECT en 13 niños entre 9 meses y 14 años, durante los últimos 6 años.