ABSTRACT
The clinical trial aimed to study the effectiveness of a dietary supplement for respiratory system diseasestherapy. Children underwent treatment during both acute and convalescent stages, and in addition to theirprimary treatment received the plant-based dietary supplement. The new plant-based dietary supplement withingredients possessing synergetic properties was developed to supplement the normal diet and help correctmetabolism disorders in the case of respiratory diseases. The ingredients for the new dietary supplementinclude echinacea purpurea, Vitamin C, rutin, zinc, and selenium. The consistent manufacturing process used toproduce the new dietary supplement ensures that the contents are protected against adverse conditions, with thecontents delivered and released at controlled rates and under specific conditions. The study of the effectivenessand the functional properties of the plant-based dietary supplement was undertaken. Children aged from 1 to 3and treated for respiratory diseases were given ½ capsule twice a day, children aged from 3 to 7 took 1 capsuletwice a day and children aged from 7 to 14 took 1 capsule three times a day as a supplement in addition to theirprimary medical treatment. At the same time, the children from the control group underwent only primarymedical treatment. The clinical trial lasted from 10 to 14 days. During the clinical trial, regular laboratory testsand chest X-rays were carried out, and such symptoms of acute respiratory illnesses like nasal congestion,hyperaemia, sore throat, cough, wheeze as well as their duration were carefully studied. The consumption of theplant-based dietary supplement resulted in faster symptoms easing and helped relieve cough, wheeze, and nasalcongestion. The data received indicates the boost to the immune response, strengthening of the immune systemas a result of taking the plant-based dietary supplement. The plant-based dietary supplement is noted to be safeand it does not cause any adverse effects. The directions for use are developed. The mandatory StateRegistration is completed and the supplement is produced in the scientific research-to-production facilities ofthe Art-Life Scientific Production Association (Tomsk city).
ABSTRACT
The paper deals with the scientifically based composition of a new food supplement. The specialized productimproves metabolism in people with nervous system disorders, its ingredients having a synergetic effect. Onetablet of the food supplement contains, mg: Gotu Kola (fruit) – 50 , L-glutamine acid - 50, motherwort - 25,lecithin - 25, gamma-aminobutyric acid - 25, calcium carbonate - 25, magnesium oxide - 25, choline bitartrate -20, guarana - 16.5, ginkgo biloba (extract) - 15, hawthorn (fruit) - 15, ginseng (root) - 13, inositol - 8, Lmethionine - 8, L-tyrosine - 7.5, L-phenylalanine - 7.5, L-caratin - 5, vitamin B3 - 5, B5-2.5, DNase - 4, RNase -4, vitamin B6 - 1, vitamin B1 - 0.5, folic acid - 0.2, vitamin B12 - 00005. The authors provide biochemicalcharacteristics of the supplement active substances to establish its functional properties and regulated qualityindicators, including nutritional value, as well as a possible mechanism of metabolism normalization. The safetycriteria comply with regulatory documents requirements, which have been proved by sanitary-hygienic andsanitary-toxicological studies.The functional properties of the specialized product and its efficacy are confirmed by conducting field trialswith a representative group of patients with angioneurosis. Taking two tablets (recommended daily dose)provides the body with the following nutrients intake (in parentheses - percentage of the recommended dailyintake): vitamin B1 – 1mg (67%); Vitamin B3 - 10 mg (50%); Vitamin B5 - 5 mg (100%); Vitamin B6 - 2.0 mg(100%); Vitamin B9 - 0.4 mg (200%); vitamin B12 - 0.001 mg (30%); magnesium - 30 mg (8%), flavoneglycosides (quercetin, campherol, isorhamnetin) - 2 mg (6%). The product composition and manufacturingtechnology have been tested and implemented at the enterprises of the company ArtLife (Tomsk), which arecertified following the requirements of the international standards of the ISO 9001, 22000 series, and GMPrules. That ensures product quality and functional properties stability.