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1.
The Korean Journal of Sports Medicine ; : 107-110, 2023.
Article in English | WPRIM | ID: wpr-1003103

ABSTRACT

Purpose@#The study was to investigate exercise capacity (peak oxygen uptake [peak VO2 ]) and pulmonary capacitance (GXcap), which is an estimate of pulmonary vascular capacitance, in patients with nonalcoholic steatohepatitis (NASH). @*Methods@#This study utilized a database of patients with NASH (n=26 [17 male and 9 female], aged 58.9±4.3 years) and healthy individuals (n=23 [12 male and 11 female, aged 58.6±7.9 years) who underwent a maximal exercise test on a recumbent cycle ergometer (Corival; Lode) in our laboratory. During cardiopulmonary exercise tests, breathing patterns and respiratory gas exchange including breathing efficiency (VE/VCO2 ) and end-tidal CO2 (PETCO2 ) were measured. In addition, peak VO2 was obtained via averaging the last 30 seconds at peak level and GXcap was obtained by calculation as follows: GXcap=oxygen pulse (O2 pulse)×PETCO2. @*Results@#The NASH group demonstrated reduced peak VO2 relative to the healthy group (17.5±8.4 mL/kg/min vs. 34±10.2 mL/kg/min, respectively; p< 0.05). In addition, there was a higher VE/VCO2 relationship in the NASH group relative to the healthy group (34.9±5.5 vs. 32.2±4.0, respectively; p< 0.05) and lower PETCO2 in the NASH group compared to the healthy group (32.8±4.0 mm Hg vs. 35.3±3.8 mm Hg, respectively; p< 0.05). Furthermore, the NASH group showed lower GXcap than the healthy group (456±150 vs. 551±202, respectively; p< 0.05). @*Conclusion@#Patients with NASH had reduced exercise capacity and pulmonary vascular capacitance relative to age-matched healthy adults and this may contribute to pulmonary pathophysiology in NASH.

2.
Rev. salud pública ; 22(4): e201, July-Aug. 2020. tab
Article in English | LILACS | ID: biblio-1139448

ABSTRACT

ABSTRACT Objective To examine the association among six forms of violence and their levels among Peruvian university students from a public University in Peru's Junin region. Materials and Methods A cross-sectional study of students of both sexes from the Faculty of Education. Sampling comprised 961 voluntary students (629 females and 332 males) studying in the education faculty from the National University of Center of Perú. Data were collected in the period July-December 2019 using the Domestic Violence Measurements Scale (VIFJ4), which assessed six forms of violence (physical, psychological, sexual, social, patrimonial, and gender). These variables were assessed through three levels of violence (mild, moderate, and severe). Results All student felt violence in their six forms. A higher percentage of violence was found in females than males. According severe level the forms of violence were ordered as follow: physical > psychological > patrimonial > social > gender. For moderate level: social > sexual > physical > gender > patrimonial > psychological, and mild level: psychological > patrimonial > gender > social > physical > sexual. Conclusion It was confirmed that there are different forms of violence and their levels in both males and females. This knowledge will serve as a basis for the development and implementation of educational programs that help university students to establish adequate behavior and mental health.(AU)


RESUMEN Objetivo Examinar la asociación entre seis formas de violencia y sus niveles entre estudiantes universitarios peruanos de una universidad pública en la región peruana de Junín. Materiales y Métodos Un estudio transversal de estudiantes de ambos sexos de la Facultad de Educación. El muestreo incluyó a 961 estudiantes voluntarios (629 mujeres y 332 hombres) que estudiaban en la Facultad de Educación de la Universidad Nacional del Centro del Perú. Los datos se recopilaron en el período de julio a diciembre de 2019 utilizando la escala de medidas de violencia doméstica VIFJ4, que evaluó seis formas de violencia (física, psicológica, sexual, social, patrimonial y de género). Estas variables fueron evaluadas a través de tres niveles de violencia (leve, moderada y severa). Resultados Todos los estudiantes sintieron violencia en sus seis formas. Se encontró un mayor porcentaje de violencia en mujeres que en hombres. Según el nivel severo, las formas de violencia se ordenaron de la siguiente manera: física > psicológica > patrimonial > social > de género. Para nivel moderado: social > sexual > físico > género > patrimonial > psicológico; nivel leve: psicológico > patrimonial > género > social > físico > sexual. Conclusión Se confirmó que existen diferentes formas de violencia y sus niveles tanto en hombres como en mujeres. Este conocimiento servirá como base para el desarrollo e implementación de programas educativos que ayuden a los estudiantes universitarios a establecer un comportamiento y una salud mental adecuados.(AU)


Subject(s)
Humans , Students , Universities , Violence/trends , Peru , Cross-Sectional Studies/instrumentation
3.
Rev. Fac. Med. Hum ; 20(3): 464-470, Jul-Sept. 2020. tab
Article in English, Spanish | LILACS-Express | LILACS | ID: biblio-1128358

ABSTRACT

La enfermedad por la nueva cepa de Coronavirus (COVID-19) ha sido catalogada como una pandemia por la OMS. En el Perú, se decretó estado de emergencia nacional y aislamiento social obligatorio desde el 15 de marzo. Los sistemas de salud a nivel mundial han sufrido un gran impacto debido la infección por COVID-19, lo cual obligó a los sistemas de salud, sociedades y asociaciones médicas a diseñar estrategias de intervención priorizada para dar continuidad a la atención de los pacientes en áreas COVID-19 y áreas libres de COVID-19. El paciente con cáncer es catalogado como vulnerable y representa un factor de riesgo para complicaciones, como ingreso a unidad de cuidados intensivos, intubación y muerte temprana por infección por COVID-19. Es así como la Asociación de Médicos Ex-Residentes de Oncología Médica (AMEROM), ha realizado esfuerzos para poder realizar recomendaciones adaptables a nuestro sistema de salud, con la finalidad de dar continuidad a la atención priorizada de los pacientes con cáncer. Mediante la metodología modificada de consenso de expertos, bajo el sustento bibliográfico, se han generado recomendaciones en diferentes etapas de la pandemia, llegando a un consenso final con recomendaciones clínicas para el manejo de pacientes oncológicos en el marco de la pandemia COVID-19 en Perú, con el fin de brindar información útil para los profesionales de la salud. El presente artículo indica los procesos con los que se llegaron a los acuerdos para dictar las recomendaciones y generar el orden de prioridad adoptado por AMEROM.


The disease by the new coronavirus strain (COVID-19) has been classified as apandemic by the WHO. In Peru, a state of national emergency and compulsory socialisolation had been declared since 15 March. Global health systems have been greatlyimpacted by COVID-19, which forced health systems, societies and medicalassociations to design prioritized intervention strategies to provide continuity of patientcare in infected areas and COVID-19-free areas. A cancer patient is classified asvulnerable and represents a risk factor for complications due to COVID-19, such asadmission to the intensive care unit, intubation, and early death due to infection due toCOVID-19. This is how the Asociación de Médicos Ex Residentes de OncologíaMédica (AMEROM), has endeavored to give recommendations adaptable to our healthsystem, to continue with the prioritized care of cancer patients. Through the modifiedmethodology of expert consensus, based on the literature, recommendations have beengenerated at different stages of the pandemic, reaching a final consensus of clinicalrecommendations for the management of cancer patients in the framework of theCOVID-19 pandemic in Peru, to provide useful information to health professionals.This article indicates the processes by which agreements were reached to makerecommendations and generate the order of priority adopted by AMEROM.

4.
Article | IMSEAR | ID: sea-191895

ABSTRACT

Background: Work related neck pain (WRNP) is common among professionals. Its cause is multifactorial and results in loss of productivity and avoidable morbidity. Aims & Objectives: To estimate the prevalence and risk factors of WRNP among the support staff of a tertiary hospital. Material & Methods: 558 support staff were randomly selected to estimate the prevalence of neck pain. Staff with severe WRNP were then included in a nested case control study to identify risk factors. Results: 37% of workers reported neck pain in the preceding 3 months. Female gender, improper posture, jobs requiring repetitive movements, perception of decreased job control, high body mass index and psychosocial stress were identified as the significant risk factors. Conclusion: Better ergonomics, improving the perception of job control and encouraging micro breaks during the work time may decrease WRNP.

5.
Singapore medical journal ; : 327-334, 2018.
Article in English | WPRIM | ID: wpr-687884

ABSTRACT

<p><b>INTRODUCTION</b>This study aimed to determine if disposable filtering facepiece respirators (FFRs) that come with an exhalation valve (EV) and a novel active venting system (AVS) provided greater perceived comfort and exertion when compared to standard N95 FFRs without these features among male military personnel performing prolonged essential outdoor duties.</p><p><b>METHODS</b>We used a randomised open-label controlled crossover study design to compare three FFR options: (a) standard FFR; (b) FFR with EV; and (c) FFR with EV+AVS. Male military personnel aged between 18 and 20 years completed a questionnaire at the start of outdoor duty (baseline), after two hours of standardised non-strenuous outdoor duty and after 12 hours of duty divided into two-hour work-rest cycles. Participants rated the degree of discomfort, exertion and symptoms using a five-point Likert scale. The association between outcomes and types of FFR was assessed using a multivariate ordered probit mixed-effects model.</p><p><b>RESULTS</b>For a majority of the symptoms, study participants gave FFR with EV and FFR EV+AVS significantly better scores than standard FFR. Both FFR with EV and FFR with EV+AVS had significantly less discomfort (FFR with EV+AVS: 91.1%; FFR with EV: 57.6%) and exertion (FFR with EV+AVS: 83.5%; FFR with EV: 34.4%) than standard FFR. FFR with EV+AVS also had significantly better scores for exertion (53.4%) and comfort (39.4%) when compared to FFR with EV.</p><p><b>CONCLUSION</b>Usage of FFR with EV+AVS resulted in significantly reduced symptoms, discomfort and exertion when compared to FFR with EV and standard FFR.</p>

6.
Braz. j. microbiol ; 48(4): 671-679, Oct.-Dec. 2017. tab, graf
Article in English | LILACS | ID: biblio-889179

ABSTRACT

ABSTRACT Thraustochytrids are unicellular protists belonging to the Labyrinthulomycetes class, which are characterized by the presence of a high lipid content that could replace conventional fatty acids. They show a wide geographic distribution, however their diversity in the Antarctic Region is rather scarce. The analysis based on the complete sequence of 18S rRNA gene showed that strain 34-2 belongs to the species Thraustochytrium kinnei, with 99% identity. The total lipid profile shows a wide range of saturated fatty acids with abundance of palmitic acid (16:0), showing a range of 16.1-19.7%. On the other hand, long-chain polyunsaturated fatty acids, mainly docosahexaenoic acid and eicosapentaenoic acid are present in a range of 24-48% and 6.1-9.3%, respectively. All factors analyzed in cells (biomass, carbon consumption and lipid content) changed with variations of culture temperature (10 °C and 25 °C). The growth in glucose at a temperature of 10 °C presented the most favorable conditions to produce omega-3fatty acid. This research provides the identification and characterization of a Thraustochytrids strain, with a total lipid content that presents potential applications in the production of nutritional supplements and as well biofuels.


Subject(s)
Seawater/microbiology , Fatty Acids/metabolism , Stramenopiles/metabolism , Phylogeny , Biotechnology , Fatty Acids/chemistry , Stramenopiles/isolation & purification , Stramenopiles/classification , Stramenopiles/genetics , Antarctic Regions
7.
Protein & Cell ; (12): 39-54, 2017.
Article in English | WPRIM | ID: wpr-757379

ABSTRACT

Human telomerase reverse transcriptase (hTERT) plays a central role in telomere lengthening for continuous cell proliferation, but it remains unclear how extracellular cues regulate telomerase lengthening of telomeres. Here we report that the cytokine bone morphogenetic protein-7 (BMP7) induces the hTERT gene repression in a BMPRII receptor- and Smad3-dependent manner in human breast cancer cells. Chonic exposure of human breast cancer cells to BMP7 results in short telomeres, cell senescence and apoptosis. Mutation of the BMPRII receptor, but not TGFbRII, ACTRIIA or ACTRIIB receptor, inhibits BMP7-induced repression of the hTERT gene promoter activity, leading to increased telomerase activity, lengthened telomeres and continued cell proliferation. Expression of hTERT prevents BMP7-induced breast cancer cell senescence and apoptosis. Thus, our data suggest that BMP7 induces breast cancer cell aging by a mechanism involving BMPRII receptor- and Smad3-mediated repression of the hTERT gene.


Subject(s)
Female , Humans , Actin-Related Protein 2 , Genetics , Metabolism , Activin Receptors, Type II , Genetics , Metabolism , Bone Morphogenetic Protein 7 , Genetics , Metabolism , Bone Morphogenetic Protein Receptors, Type II , Genetics , Metabolism , Breast Neoplasms , Genetics , Metabolism , Cellular Senescence , HeLa Cells , MCF-7 Cells , Neoplasm Proteins , Genetics , Metabolism , Protein Serine-Threonine Kinases , Genetics , Metabolism , Receptor, Transforming Growth Factor-beta Type II , Receptors, Transforming Growth Factor beta , Genetics , Metabolism , Smad3 Protein , Genetics , Metabolism , Telomerase , Genetics , Metabolism , Telomere Homeostasis
8.
Journal of Veterinary Science ; : 17-23, 2017.
Article in English | WPRIM | ID: wpr-224463

ABSTRACT

Sepsis causes significant mortality in neonatal foals; however, there is little data describing the cellular and molecular pathways of lung inflammation in septic foals. This study was conducted to characterize lung inflammation in septic foals. Lung tissue sections from control (n = 6) and septic (n = 17) foals were compared using histology and immunohistology. Blinded pathologic scoring of hematoxylin and eosin stained samples revealed increased features of lung inflammation such as thickened alveolar septa and sequestered inflammatory cells in septic foals. Septic foal lungs showed increased expression of von Willebrand factor in blood vessels, demonstrating vascular inflammation. Use of MAC387 antibody to detect calprotectin as a reflection of mononuclear cell infiltration revealed a significant increase in their numbers in alveolar septa of lungs from septic foals compared to those from control foals. The mononuclear cells appeared to be mature macrophages and were located in the septal capillaries, suggesting they were pulmonary intravascular macrophages (PIMs). Finally, lungs from septic foals showed increased expression of Toll-like receptor 4 and 9 in mononuclear cells relative to the control. Taken together, this study is the first to show the expression of inflammatory molecules and an increase in PIMs in lungs from foals that died from sepsis.


Subject(s)
Blood Vessels , Capillaries , Eosine Yellowish-(YS) , Hematoxylin , Horses , Immunohistochemistry , Inflammation , Leukocyte L1 Antigen Complex , Lung , Macrophages , Mortality , Pneumonia , Sepsis , Toll-Like Receptor 4 , Toll-Like Receptors , von Willebrand Factor
9.
Rev. colomb. cienc. pecu ; 28(3): 238-246, jul.-sep. 2015. ilus, tab
Article in English | LILACS | ID: lil-757271

ABSTRACT

Background: litter provides comfort to animals while improving productive performance and carcass quality. Objective: this study evaluated broiler performance, incidence of contact dermatitis, and quality of poultry litter of wood shavings and/or sugarcane bagasse (SB) after five consecutive flocks. Methods: two thousand birds were raised in five consecutive flocks composed of 400 chicks each. The experiment was set in a completely randomized design with five treatments and four repetitions. The treatments consisted of substituting wood shavings with different levels of SB (0, 25, 50, 75, and 100%). Results: litter density, pH, dry matter content, total nitrogen, and phosphorus did not vary between treatments. However, substituting wood shavings with SB increased moisture retention capacity of the litter and ammonia production. Neither carcass lesions nor productive performance, with the exception of weight gain and feed conversion ratio in the fifth flock, differed between treatments. Conclusions: substituting 75% of wood shavings with SB maintained litter quality and improved poultry performance.


Antecedentes: la cama propicia el confort y mejora el desempeño productivo y la calidad de la canal de los pollos de engorde. Objetivo: el objetivo del presente estudio fue evaluar el desempeño productivo de pollos de engorde, la incidencia de dermatitis de contacto en la canal y la calidad de la cama de pollo compuesta de viruta de madera y/o bagazo de caña de azúcar (SB), usada en cinco lotes consecutivos. Métodos: dos mil aves fueron criadas en cinco lotes consecutivos, cada uno constituido por 400 pollitos, en un diseño completamente aleatorizado con cinco tratamientos y cuatro repeticiones. Los tratamientos consistieron en diferentes niveles de sustitución de viruta de madera con SB (0, 25, 50, 75 y 100%). Resultados: la densidad, pH y contenidos de materia seca, nitrógeno total y fósforo no variaron entre los tratamientos. Sin embargo, sustituir viruta de madera con SB aumentó la capacidad de retención de humedad y la cantidad de amoníaco volatilizado en el galpón. Ni las lesiones en la canal y ni el desempeño productivo, con excepción de la ganancia de peso y conversión alimentaria en el quinto lote, difirieron entre los tratamientos. Conclusiones: sustituir 75% de la viruta de madera con SB mantuvo la calidad de la cama y mejoró el desempeño productivo de las aves.


Antecedentes: cama de frango propicia conforto e melhora o desempenho produtivo e a qualidade da carcaça das aves. Objetivo: este estudo avaliou o desempenho produtivo de frangos de corte, a incidência de dermatite de contato na carcaça e a qualidade da cama de frango composta de maravalha e/ou bagaço de cana (SB), usada em cinco lotes consecutivos. Métodos: duas mil aves foram criadas em cinco lotes consecutivos, compostos de 400 pintinhos cada, em delineamento inteiramente casualizado com cinco tratamentos e quatro repetições. Os tratamentos consistiram de diferentes níveis de substituição de maravalha com BC (0, 25, 50, 75 e 100%). Resultados: densidade, pH e teores de matéria seca, nitrogênio total e fósforo não variaram entre os tratamentos. Entretanto, substituir maravalha com SB aumentou a capacidade de retenção de umidade e a quantidade de amônia volatilizada no galpão. Nem as lesões na carcaça e nem o desempenho produtivo, com exceção do ganho de peso e conversão alimentar no quinto lote, diferiram entre os tratamentos. Conclusões: substituir 75% da maravalha com SB manteve a qualidade da cama e melhorou o desempenho produtivo das aves.

10.
Braz. j. phys. ther. (Impr.) ; 17(5): 479-486, out. 2013. graf
Article in English | LILACS | ID: lil-689926

ABSTRACT

BACKGROUND: Although a number of studies have compared the influence of different electrical pulse parameters on maximum electrically induced torque (MEIT) and discomfort, the role of phase duration has been poorly investigated. OBJECTIVE: To examine the variation in muscle torque and discomfort produced when electrically stimulating quadriceps femoris using pulsed current with three different phase durations in order to establish whether there are any advantages or disadvantages in varying the phase duration over the range examined. METHOD: This is a two repeated-measures, within-subject study conducted in a research laboratory. The study was divided into 2 parts with 19 healthy young adults in each part.In part 1, MEIT was determined for each phase duration (400, 700, and 1000 µs), using a biphasic pulsed current at a frequency of 50 Hz. In part 2, stimulus amplitude was increased until the contractions reached 40% of maximum voluntary isometric contraction (MVIC) and the associated discomfort produced by each phase duration was measured. RESULTS: In part 1 of the study, we found that the average MEITs generated with each phase duration (400, 700, and 1000 µs) were 55.0, 56.3, and 58.0% of MVIC respectively, but the differences were not statistically significant (p=.45). In part 2, we found a statistically significant increase in discomfort over the same range of phase durations. The results indicate that, for a given level of torque production, discomfort increases with increasing phase duration (p=.008). CONCLUSIONS: Greater muscle torque cannot be produced by increasing the stimulus phase duration over the range examined. Greater discomfort is produced by increasing the stimulus phase duration. .


Subject(s)
Female , Humans , Young Adult , Electric Stimulation/methods , Quadriceps Muscle/physiology , Electric Stimulation/adverse effects , Time Factors , Torque
11.
Pesqui. vet. bras ; 32(10): 1045-1049, out. 2012. tab
Article in Portuguese | LILACS | ID: lil-654398

ABSTRACT

O objetivo desta pesquisa foi realizar um diagnóstico qualitativo dos gêneros de parasitos encontrados em amostras fecais ambientais de jacarés (Caiman latirostris Daudin, 1802), criados comercialmente em sistema fechado, no período de 2008 a 2009, no estado do Rio de Janeiro. Um total de 300 amostras foi coletado de 150 filhotes, 80 de animais de engorda e 70 de reprodução, e submetido a análises coproparasitológicas, de flutuação (método de Willis-Mollay) e sedimentação simples (método de Lutz), de acordo com Hoffmann (1987). As amostras foram visualizadas à luz da microscopia óptica. Os resultados obtidos evidenciaram a presença de oocistos de Eimeria e Isospora, cistos de Balantidium e ovos de Acanthostomum e Dujardinascaris.


The objective of this paper was to diagnose qualitatively parasite genera found in environmental fecal samples of alligators (Caiman latirostris Daudin, 1802) commercially bred from 2008 to 2009 in a closed farming system in the state of Rio de Janeiro. A total of 300 samples were collected from 150 young, 80 fattening and 70 breeding processed by two different methods, the flotation (method of Willis-Mollay) and simple sedimentation (method of Lutz), according to Hoffmann (1987). The samples were then examined by optical microscopy. The results revealed presence of Eimeria and Isospora oocysts, Balantidium cysts, and Acanthostomum and Dujardinascaris eggs.


Subject(s)
Animals , Parasitic Diseases, Animal/transmission , Diet , Feces/parasitology , Alligators and Crocodiles/parasitology , Balantidium , Eimeria , Isospora
12.
Rev. biol. trop ; 60(2): 735-743, June 2012. ilus, graf, mapas, tab
Article in English | LILACS | ID: lil-657815

ABSTRACT

White-tip reef sharks are common inhabitants of the shallow waters surrounding the Galapagos Islands, where several known aggregation sites have become touristic attractions. With the aim to describe site fidelity and residency patterns of the white-tip reef sharks in a saltwater creek, we used the ultrasonic telemetry method. The study was undertaken in a saltwater channel South of Academy Bay, Santa Cruz Island, from May 2008-September 2009. A total of nine transmitters were attached to sharks and ultrasonic receivers were deployed at the inner and outside areas of the creek. From the total of fitted sharks, four lost their transmitters. The results obtained with the remaining sharks showed an elevated use of the inner area of the channel during the day, with more use of the external area during the night. However, none of the sharks were detected at the site every day, suggesting that they may have a number of preferred sites within their home range. More studies are needed to detail the home range and habitat use of this species, and to guide its protection level in the AcademyBay area. Rev. Biol. Trop. 60 (2): 735-743. Epub 2012 June 01.


Los tiburones punta blanca de arrecife son habitantes comunes de las aguas que rodean las Islas Galápagos, por lo que muchos de sus sitios de agregación se han convertido en atractivos turísticos. Con el objetivo de describir la fidelidad del sitio y los patrones de residencia de nueve tiburones desde mayo 2008-septiembre 2009, se utilizó telemetría ultrasónica en un canal de agua salada en el sur de Bahía Academia, Isla Santa Cruz. A pesar de que cuatro tiburones perdieron sus transmisores, los restantes tiburones monitoreados mostraron un uso elevado del interior del canal durante el día y del exterior durante la noche. Sin embargo, ninguno de los tiburones fue detectado en el sitio diariamente, lo cual sugiere que deben tener un número mayor de sitios preferidos dentro de su área de vida.


Subject(s)
Animals , Behavior, Animal/physiology , Ecosystem , Sharks/physiology , Ecuador , Population Dynamics , Sharks/classification , Telemetry
13.
Article in English | IMSEAR | ID: sea-139251

ABSTRACT

Background. Diabetes is a lifestyle disease and can be successfully managed by good self-care activities such as diet, exercise, monitoring and drug adherence. Adequate baseline information about the prevalence of good self-care activities is not available from India. We aimed to estimate the existing self-care behaviours and factors influencing these behaviours among adult patients with type 2 diabetes in urban southern India. Methods. A cross-sectional survey was conducted using a cluster design in an urban community in southern India. The Summary Diabetes Self-Care Activities questionnaire was used to collect information on diet, exercise, monitoring of blood sugars and adherence to drugs. Risk factors such as marital status, socioeconomic status, depression, benefit-finding and duration of illness, which are likely to influence self-care behaviour, were assessed. Results. Good dietary behaviour was present in 29% (95% CI 20.8%–37.2%), good exercise behaviour in 19.5% (95% CI 17.4%–21.6%), regular blood sugar monitoring in 70% (95% CI 62.2%–77.8%) and drug adherence in 79.8% (95% CI 75.1%–84.5%). Being male (OR 3.38; 95% CI 1.541–7.407) and married (OR 5.60; 95% CI 1.242–25.212) significantly favoured good exercise behaviour. Being married (OR 2.322; 95% CI 1.104– 4.883) and belonging to the higher socioeconomic status (OR 2.713; 95% CI 1.419–5.190) were significantly associated with monitoring of blood sugars. Conclusions. Self-care activities with respect to diet and exercise are poor in the population studied. The self-care activities relating to blood sugar monitoring and drug adherence are good. Improving self-care behaviour among patients with diabetes in India should start with adequate targeted health education.


Subject(s)
Adult , Aged , Aged, 80 and over , Diabetes Mellitus, Type 2/epidemiology , Diabetes Mellitus, Type 2/therapy , Female , Health Surveys , Humans , India/epidemiology , Male , Middle Aged , Residence Characteristics , Self Care/statistics & numerical data , Urban Population/statistics & numerical data
14.
Protein & Cell ; (12): 333-346, 2011.
Article in English | WPRIM | ID: wpr-757092

ABSTRACT

Estrogen is implicated as playing an important role in aging and tumorigenesis of estrogen responsive tissues; however the mechanisms underlying the mitogenic actions of estrogen are not fully understood. Here we report that estrogen deficiency in mice caused by targeted disruption of the aromatase gene results in a significant inhibition of telomerase maintenance of telomeres in mouse ovaries in a tissue-specific manner. The inhibition entails a significant shortening of telomeres and compromised proliferation in the follicular granulosa cell compartment of ovary. Gene expression analysis showed decreased levels of proto-oncogene c-Myc and the telomerase catalytic subunit, telomerase reverse transcriptase (TERT), in response to estrogen deficiency. Estrogen replacement therapy led to increases in TERT gene expression, telomerase activity, telomere length and ovarian tissue growth, thereby reinstating ovary development to normal in four weeks. Our data demonstrate for the first time that telomere maintenance is the primary mechanism mediating the mitogenic effect of estrogen on ovarian granulosa cell proliferation by upregulating the genes of c-Myc and TERT in vivo. Estrogen deficiency or over-activity may cause ovarian tissue aging or tumorigenesis, respectively, through estrogen regulation of telomere remodeling.


Subject(s)
Animals , Female , Humans , Mice , 46, XX Disorders of Sex Development , Drug Therapy , Genetics , Metabolism , Aging , Genetics , Metabolism , Aromatase , Genetics , Metabolism , Cell Proliferation , Estrogen Replacement Therapy , Estrogens , Pharmacology , Gene Expression , Genes, myc , Genetics , Granulosa Cells , Metabolism , Pathology , Gynecomastia , Drug Therapy , Genetics , Metabolism , Infertility, Male , Drug Therapy , Genetics , Metabolism , Metabolism, Inborn Errors , Drug Therapy , Genetics , Metabolism , Mice, Knockout , Telomerase , Genetics , Metabolism , Telomere , Chemistry , Metabolism , Pathology
17.
Interaçöes estud. pesqui. psicol ; 9(17): 71-89, jan.-jun. 2004. tab
Article in Portuguese | LILACS | ID: lil-463579

ABSTRACT

O objetivo do estudo foi caracterizar a formação e a atuação do psicólogo vinculado às unidades básicas de saúde de Natal - RN. Uma entrevista semi-estruturada foi aplicada a 28 profissionais dos 4 distritos sanitários. Os resultados mostram que 93 por cento são do sexo feminino, 46 por cento têm idade entre 30-40 anos, 89 por cento se graduaram na UFRN fazendo estágio em clínica (69 por cento), 89 por cento buscaram estudos pós-graduados, 54 por cento realizaram unicamente psicoterapia e 46 por cento aliada a outras atividades. São discutidas a marcante presença da atividade psicoterapêutica na prática do psicólogo; a desvinculação do trabalho dos princípios do SUS; a dificuldade de ultrapassar as concepções individualistas e psicologizantes dos problemas sociais em virtude da cultura profissional do psicólogo. A não adoção do conceito de saúde que implicaria uma concepção e atenção diferenciadas, equânimes e preventivas, dificulta as ações que diferem do modelo assistencial-curativo, reinante no ordenamento das políticas e na ações de saúde


Subject(s)
Humans , Female , Adult , Professional Practice , Psychology , Public Health
18.
Interaçao psicol ; 7(2): 23-30, jun.-dez. 2003.
Article in Portuguese | LILACS | ID: lil-410123

ABSTRACT

O presente estudo teve por objetivo atualizar informações acerca da situação do psicólogo norte-rio-grandense, focalizando sua atenção, em especial, na atuação profissional. Um questionário contendo três conjuntos de questões (Dados Gerais, Formação Acadêmica e Atividades Profissionais) foi aplicado em 192 psicólogos (28,5 por cento do total do Estado). Os principais resultados mostram que os psicólogos do Estado são predominantemente do sexo feminino (90 por cento), com idade inferior a 40 anos (67,2 por cento), formados na Universidade Federal do Rio Grande do Norte (71 por cento), 55 por cento deles com alguma formação pós-graduada. As principais atividades desempenhadas pelos psicólogos são a psicoterapia (59,9 por cento), seguida por atividades acadêmicas diversas, seleção profissional e avaliação psicológica. Os psicólogos exercem tais atividades em clínicas psicológicas (35,9 por cento), seguidas de unidades públicas de saúde e instituições educacionais. Dentre outros aspectos, são discutidas a marcante presença da atividade psicoterapêutica, a abrangência e a dispersão das atividades desenvolvidas e as chamadas inovações na Psicologia


Subject(s)
Adult , Psychology , Credentialing , Professional Practice/trends
19.
Arq. neuropsiquiatr ; 55(3B): 598-605, set. 1997. tab
Article in Portuguese | LILACS | ID: lil-205361

ABSTRACT

O distúrbio de hiperatividade com déficit de atençäo constitui síndrome comum na infância, pelo que é reconhecido como problema médico-social importante, sendo objeto de extensa investigaçäo quanto aos seus determinantes, abordagens diagnósticas e formas de prevençäo e tratamento. Dentro dos fatores que podem alterar a funçäo cerebral, encontra-se a desnutriçäo. Os autores discutem a associaçäo da síndrome com o estado nutricional de uma populaçäo de escolares.


Subject(s)
Child , Humans , Male , Female , Attention Deficit Disorder with Hyperactivity/etiology , Nutrition Disorders/complications , Nutritional Status , Analysis of Variance , Attention Deficit Disorder with Hyperactivity/diagnosis , Confidence Intervals , Cross-Sectional Studies , Neurologic Examination , Nutrition Disorders/diagnosis , Prevalence , Random Allocation
20.
Indian J Med Sci ; 1967 Apr; 21(4): 229-31
Article in English | IMSEAR | ID: sea-69265
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